估计葡萄糖处置率在评估1型糖尿病患者胰岛素抵抗中的应用价值  

Application value of estimating glucose disposal rate in evaluating insulin resistance in patients with type 1 diabetes mellitus

作　　者：任留留 陈爱荣[2] 陆静 张丽娟 Ren Liuliu;Chen Airong;Lu Jing;Zhang Lijuan(The Second Clinical Medicine School,Lanzhou University,Lanzhou 730000,China;Department of Endocrinology and Metabolism,the Second Hospital of Lanzhou University,Lanzhou 730000,China)

机构地区：[1]兰州大学第二临床医学院,兰州730000 [2]兰州大学第二医院内分泌与代谢病科,兰州730000

出　　处：《国际内分泌代谢杂志》2023年第3期229-232,共4页International Journal of Endocrinology and Metabolism

摘　　要：1型糖尿病(T1DM)在临床中以胰岛素绝对缺乏为特征。随着生活方式的改变、外源性胰岛素的强化治疗、血糖控制不佳, 胰岛素抵抗(IR)在T1DM中也引起人们的重视。IR是预测T1DM发生心血管疾病及并发症的一个重要危险因素, 但在临床实践中难以评估。利用估计葡萄糖处置率作为间接评估T1DM是否存在IR的工具, 并可以预测糖尿病并发症风险。因此, 早期识别T1DM中是否合并IR将有助于风险分层, 除了优化降糖之外, 可以早期通过改变生活方式或药物治疗改善IR并预防慢性并发症从而改善该人群的预后和生活质量。Type 1 diabetes mellitus(T1DM)is characterized by absolute insulin deficiency.With the change of lifestyle,the intensive treatment of exogenous insulin and the poor control of blood glucose,insulin resistance(IR)has also attracted people′s attention in T1DM.IR is an important risk factor for predicting cardiovascular disease and complications of diabetes in T1DM,but it is difficult to evaluate in clinical practice.The estimated glucose disposal rate is used as a tool to indirectly evaluate whether there is IR in T1DM,and can predict the risk of complications of diabetes.Therefore,early identification and combination of IR in T1DM will help to stratify the risk.In addition to optimizing hypoglycemic therapy,early lifestyle changes or drug treatment can improve IR and prevent chronic complications,so as to improve the prognosis and quality of life of this group of T1DM.

关 键 词：估计葡萄糖处置率 胰岛素抵抗 1型糖尿病 糖尿病并发症 

分 类 号：R587.1[医药卫生—内分泌]