坏死性凋亡与糖尿病及慢性微血管并发症关系的研究进展  

Research progress on the relationship between necroptosis and diabetes mellitus and chronic microvascular complications

作　　者：李丽[1] 曹明明 Li Li;Cao Mingming(Endocrinology Department,the First Affiliated Hospital of Harbin Medical University,Haerbin 150000,China)

机构地区：[1]哈尔滨医科大学附属第一医院内分泌科,哈尔滨150000

出　　处：《国际内分泌代谢杂志》2023年第3期233-236,共4页International Journal of Endocrinology and Metabolism

基　　金：国家自然科学基金项目(82100884);国家重点研发计划(2018YFC1313902)。

摘　　要：糖尿病是21世纪全球面临的最严重、最危急的健康问题之一。我国糖尿病患者人数目前位居全球第一。糖尿病微血管病变是糖尿病最普遍的并发症, 严重影响人们的生活质量。坏死性凋亡是近年来发现的一种新型的细胞程序性死亡途径, 参与炎症反应。研究表明坏死性凋亡参与糖尿病的发病过程, 抑制坏死性凋亡可以减轻糖尿病慢性微血管并发症的发生。该综述就坏死性凋亡在糖尿病及其微血管并发症中的作用机制展开论述。Diabetes mellitus is one of the most serious and critical health problems in the 21st century.At present,the number of diabetes patients in our country ranks first in the world.Diabetic microangiopathy is one of the most common complications of diabetes mellitus,which affects people′s quality of life seriously.Necroptosis is a new found programmed cell death pathway,which is involved in inflammatory reaction.Studies have shown that necroptosis is involved in the pathogenesis of diabetes mellitus,and inhibition of necroptosis can reduce the occurrence of chronic microvascular complications of diabetes mellitus.This review focuses on the role of necroptosis in diabetes and its microvascular complications.

关 键 词：坏死性凋亡 受体相互作用蛋白激酶1/3 混合谱系激酶结构域样蛋白 糖尿病 糖尿病微血管并发症 

分 类 号：R587.2[医药卫生—内分泌]