非高密度脂蛋白-胆固醇与主要心电图异常的相关性分析  

Association of non-high-density lipoprotein cholesterol with major abnormal electrocardiogram

作　　者：汪丽 鱼馨文 陈艳艳 徐谦 姬秋和 Wang Li;Yu Xinwen;Chen Yanyan;Xu Qian;Ji Qiuhe(Department of Endocrinology,the First Affiliated Hospital of Air Force Medical University,Xi′an 710032,China;Department of Endocrinology,the Second Affiliated Hospital of Air Force Medical University,Xi′an 710038,China)

机构地区：[1]空军军医大学第一附属医院内分泌科,西安710032 [2]空军军医大学第二附属医院内分泌科,西安710038

出　　处：《国际内分泌代谢杂志》2023年第3期237-241,共5页International Journal of Endocrinology and Metabolism

基　　金：陕西省重点研发计划(2017ZDCXL-SF-02-01)。

摘　　要：目的探讨中国成年人群不同非高密度脂蛋白-胆固醇(non-HDL-C)水平与明尼苏达代码指示的主要心电图异常(MA-ECG)之间的关系。方法从2007—2008年中国糖尿病和代谢紊乱研究中, 筛选出资料齐全的34 000人, 采用χ2检验、单因素方差分析比较不同组别各项指标及MA-ECG占比的差异。采用Logistic回归分析non-HDL-C与MA-ECG及其各编码的相关性, 并评估各危险因素与non-HDL-C对MA-ECG发生风险有无交互作用。结果随着non-HDL-C水平的上升, MA-ECG占比也显著升高。校正混杂因素后, non-HDL-C与MA-ECG的发生独立相关;1-和4-、5-代码发生风险与non-HDL-C显著正相关, 6-和8-代码发生风险则与non-HDL-C呈负相关;年龄、体重指数、高血压均对non-HDL-C与MA-ECG间的相关性存在交互作用。结论 Non-HDL-C水平升高是MA-ECG的独立危险因素, 提示应早期关注non-HDL-C水平升高的人群, 及时做心电图筛查, 尽早发现CVD高危风险个体并予以干预。Objective We aimed to analyze the association between non-high-density lipoprotein cholesterol(non-HDL-C)level and Minnesota code-indicated major electrocardiogram abnormality(MA-ECG)among Chinese adult population.Methods From the Chinese Diabetes and Metabolic Disorders study from 2007 to 2008,34,000 people with complete data were screened,and one-way ANOVA andχ2 test were performed to make comparisons of the differences of each index and the percentage of MA-ECG among different groups.Logistic regression was used to analyse the correlation of non-HDL-C with MA-ECG and each MA-ECG Minnesota code.And the interaction of each risk factor with non-HDL-C on the risk of MA-ECG was also assessed.Results As non-HDL-C levels increased,the percentage of MA-ECG also increased significantly.Logistic regression analysis showed that non-HDL-C was independently associated with MA-ECG after correcting for confounding factors;the risk of 1-and 4-and 5-code occurrence was significantly positively correlated with non-HDL-C,while the risk of 6-and 8-code occurrence was negatively correlated with non-HDL-C;age,body mass index,and hypertension were all interacted with the correlation between non-HDL-C and MA-ECG.Conclusion Elevated non-HDL-C levels are an independent risk factor for MA-ECG,suggesting early attention to those with elevated non-HDL-C levels and timely ECG screening to identify and intervene early in individuals at high risk of CVD.

关 键 词：非高密度脂蛋白-胆固醇 主要心电图异常 明尼苏达编码 心血管疾病 

分 类 号：R540.41[医药卫生—心血管疾病] R589[医药卫生—内科学]