5∶2轻断食对代谢综合征患者体重及糖脂代谢的影响  

Effect of 5∶2 fasting diet on body weight and glucose and lipid metabolism in patients with metabolic syndrome

作　　者：肖艳新[1] 马朝朋 吴晓丹 王红素 王君[1] Xiao Yanxin;Ma Zhaopeng;Wu Xiaodan;Wang Hongsu;Wang Jun(Department of Endocrinology,Baoding NO.1 Central Hospital,Baoding 071000,China;Department of Radiology,the 82nd Army Hospital of the PLA,Baoding 071000,China)

机构地区：[1]保定市第一中心医院内分泌科,保定071000 [2]解放军陆军第82集团军医院放射科,保定071000

出　　处：《国际内分泌代谢杂志》2023年第3期242-246,共5页International Journal of Endocrinology and Metabolism

摘　　要：目的观察5∶2轻断食对肥胖代谢综合征患者体重及糖脂代谢的影响。方法选取肥胖代谢综合征患者56例, 分为5∶2轻断食治疗组(n=36)及一般饮食控制治疗组(n=20), 给予5∶2轻断食及一般饮食控制治疗16周。观察治疗后患者身体形态指标和代谢指标变化。结果治疗16周后, 5∶2轻断食治疗组各身体形态指标包括体重、体重指数、腰围、骨骼肌、体脂肪、体脂率、内脏脂肪面积均较治疗前显著下降(P<0.05);代谢指标包括收缩压、舒张压、总胆固醇、低密度-脂蛋白胆固醇、甘油三酯、空腹血糖、餐后2 h血糖、尿酸及稳态模型-胰岛素抵抗指数(HOMA-IR)水平较治疗前显著下降, 高密度脂蛋白-胆固醇水平显著升高(P<0.05)。与一般饮食控制治疗组比较, 5∶2轻断食治疗组在治疗16周后体重指数、体脂肪、体脂率及内脏脂肪面积、收缩压、舒张压、低密度脂蛋白-胆固醇、甘油三酯、空腹血糖、餐后2 h血糖、HOMA-IR水平更低(P<0.05)。治疗16周后, 5∶2轻断食治疗组肥胖、血脂异常、高尿酸血症、糖代谢异常及非酒精性脂肪肝比例较治疗前下降(P<0.05)。结论 5∶2轻断食能够降低代谢综合征患者的体重、体脂率, 改善糖脂代谢紊乱, 减轻胰岛素抵抗, 且优于一般饮食控制治疗。Objective To observe the effect of 5∶2 intermittent fasting diet on body weight and metabolic profile in patients with metabolic syndrome.Methods A total of 56 obese patients with metabolic syndrome were divided into 5∶2 intermittent fasting treatment group(n=36)and general diet control treatment group(n=20).Patients in each group received 5∶2 intermittent fasting and general diet control for 16 weeks.Body shape indexes and metabolic profile were observed after treatment.Results After 16 weeks of treatment,all body shape indexes such as body mass index,waist circumference,skeletal muscle content,body fat,body fat rate and visceral fat area in the 5∶2 intermittent fasting treatment group decreased significantly compared with those before treatment(P<0.05).The levels of metabolic profile including systolic blood pressure,diastolic blood pressure,total cholesterol,low-density lipoprotein cholesterol,triglycerides,fasting blood glucose,2 hour postprandial blood glucose,uric acid and HOMA-IR decreased significantly compared with those before treatment,and the level of high-density lipoprotein cholesterol increased significantly(P<0.05).Compared with general diet control group,body mass index,body fat,body fat rate and visceral fat area,systolic blood pressure,diastolic blood pressure,low density lipoprotein cholesterol,triglyceride,fasting blood glucose,2 hour postprandial blood glucose and HOMA-IR level in the 5∶2 intermittent fasting treatment group were lower after 16 weeks of treatment(P<0.05).After 16 weeks of treatment,the proportion of obesity,dyslipidemia,hyperuricemia,abnormal glucose metabolism and nonalcoholic fatty liver disease in the 5∶2 intermittent fasting treatment group decreased compared with that before treatment(P<0.05).Conclusions 5∶2 intermittent fasting diet can reduce body weight and body fat ratio of patients with metabolic syndrome,improve the disorder of glucose and lipid metabolism and reduce insulin resistance,and is better than general diet control treatment.

关 键 词：5∶2轻断食 代谢综合征 肥胖 

分 类 号：R589[医药卫生—内分泌]