2型糖尿病患者血糖波动与血清CD147、MMP-9水平的相关性研究  

Study on the correlation between blood glucose fluctuation and serum CD147, MMP-9 level in type 2 diabetic patients

作　　者：刘婷婷[1] 蒙绪标[1] 陈绵雄[1] Liu Tingting;Meng Xubiao;Chen Mianxiong(Department of Endocrinology,Haikou People′s Hospital,Haikou,570208,China)

机构地区：[1]海口市人民医院内分泌科,海口570208

出　　处：《国际内分泌代谢杂志》2023年第3期252-256,共5页International Journal of Endocrinology and Metabolism

基　　金：2019年海南省卫生计生行业科研项目(19A200066)。

摘　　要：目的探讨血糖波动与血清细胞外基质金属蛋白酶诱导因子(CD147)、基质金属蛋白酶9(MMP-9)的相关性。方法纳入2019年6月至2020年6月海口市人民医院医院收治的172例2型糖尿病患者, 根据平均血糖波动幅度(MAGE)分为正常血糖波动组(n=88)和异常血糖波动组(n=84)。记录一般临床资料, 测定生化指标和CD147、MMP-9水平, logistic回归分析2型糖尿病患者血糖波动的影响因素。结果与正常血糖波动组相比, 异常血糖波动组患者的体重指数(BMI)、腰围、吸烟比例及稳态模型-胰岛素抵抗指数(HOMA-IR)指数较大, 空腹血糖(FBG)、糖化血红蛋白A1c(HbA1c)水平高(P均<0.05)。与正常血糖波动组相比, 异常血糖波动组患者CD147、MMP-9水平均显著升高(P均<0.001)。CD147和MMP-9与血糖标准差(SDBG)、平均血糖水平(MBG)、MAGE、日间血糖平均绝对差(MODD)、平均餐后血糖波动幅度(MPPGE)、最大血糖波动幅度(LAGE)均呈正相关(P<0.05)。病程、HbA1c、CD147、MMP-9是2型糖尿病患者血糖波动的独立影响因素(P<0.05)。结论 2型糖尿病患者血糖波动与血清CD147、MMP-9密切相关, 但CD147和MMP-9是否介导了血糖波动对2型糖尿病患者血管的损伤需进一步研究。Objective To explore the correlation between blood glucose fluctuation and level of extracellular matrix metalloproteinase inducer(CD147)and matrix metalloproteinase 9(MMP-9),and analyze the influencing factors of blood glucose fluctuation.Methods A total of 172 patients with type 2 diabetes admitted to Haikou People′s Hospital from June 2019 to June 2020 were included.They were divided into normal blood glucose fluctuation group(n=88)and abnormal blood glucose fluctuation group(n=84)according to the average blood glucose fluctuation range(MAGE).General clinical data were recorded,and biochemical indexes and CD147,MMP-9 levels were measured,and the influencing factors of blood glucose fluctuation in type 2 diabetes patients were analyzed by logistic regression.Results Compared with the normal blood glucose fluctuation group,the body mass index(BMI),waist circumference,smoking proportion and homeostasis model insulin resistance index(HOMA-IR)of patients with abnormal blood glucose fluctuation group were higher,and the levels of fasting blood glucose(FBG)and glycosylated hemoglobin(HbA1c)were also higher(P<0.05).Compared with the normal blood glucose fluctuation group,the CD147 and MMP-9 levels in the abnormal blood glucose fluctuation group were significantly higher(P<0.001).The level of CD147 and MMP-9 were positively correlated with standard deviation of blood glucose(SDBG),mean blood glucose level(MBG),MAGE,mean absolute difference of blood glucose during the day(MODD),mean postprandial blood glucose fluctuation range(MPPGE)and maximum blood glucose fluctuation range(LAGE)(P<0.05).The course of disease,HbA1c,CD147 and MMP-9 level were independent risk factors of blood glucose fluctuation in type 2 diabetes patients(P<0.05).Conclusion The fluctuation of blood sugar in patients with type 2 diabetes mellitus is closely related to CD147 and MMP-9,which may become a new index to evaluate the fluctuation of blood sugar in patients with type 2 diabetes mellitus.

关 键 词：2型糖尿病 血糖波动 CD147 基质金属蛋白酶9 

分 类 号：R587.1[医药卫生—内分泌]