针刺通过调节睡眠结构改善失眠的神经递质机制研究进展  

Progress of mechanism research on the neurotransmitters in treatment of insomnia with acupuncture by regulating sleep architecture

作　　者：李仲文 诸毅晖[1] 宋孝军 刘薪雨 廖凌鑫 LI Zhong-wen;ZHU Yi-hui;SONG Xiao-jun;LIU Xin-yu;LIAO Ling-xin(School of Acupuncture-Moxibustion and Tuina,Chengdu University of TCM,Chengdu 610075,China)

机构地区：[1]成都中医药大学针灸推拿学院,成都610075

出　　处：《针刺研究》2023年第6期618-624,共7页Acupuncture Research

基　　金：国家自然科学基金面上项目(No.81673885)。

摘　　要：失眠患者的低质量睡眠与睡眠结构失衡及神经递质紊乱密切相关。针刺可减少浅睡眠时间及其比例,增加深睡眠和快速眼动睡眠时间及其比例,从而调整睡眠结构。本文总结了针刺通过调节5-羟色胺、去甲肾上腺素、多巴胺、γ-氨基丁酸、乙酰胆碱、食欲素等改善睡眠结构的相关研究,探索针刺对神经递质的作用特点及神经递质调控睡眠结构的具体表现,以期为针刺改善失眠提供文献依据,并为针刺调整睡眠结构的机制研究提供思路。Low-quality sleep in patients with insomnia is closely related to sleep architecture imbalance and neurotransmitter impairment.Acupuncture may reduce the duration of light sleep and its proportion,increase the time of deep sleep and rapid-eye-movement sleep as well as their proportions so as to modulate the sleep architecture for insomnia.The paper summarized the related studies of acupuncture for improving sleep architecture through regulating serotonin,norephinephrine,dopamine,γ-aminobutyric acid,acetylcholine and orexin;and explored the effects of acupuncture on the neurotransmitters and their specific performance in regulating sleep architecture.It is anticipated that the review may provide the literature evidences of acupuncture for improving sleep quality in patients with insomnia,and the approaches to the mechanism research of acupuncture for regulating sleep architecture.

关 键 词：针刺 睡眠结构 神经递质 综述 

分 类 号：R246.6[医药卫生—针灸推拿学]