半夏白术天麻汤加减治疗原发性高血压病痰湿中阻证的临床研究  

Clinical study on the treatment of Phlegm dampness obstruction syndrome in essential hypertension with Banxia Baizhu Tianma Decoction(半夏白术天麻汤)

作　　者：王晨[1] 杨威[1] 孙芳 金杰[2] WANG Chen;YANG Wei;SUN Fang;JIN jie(Huanghe Central Hospital,Zhengzhou 45000,Henan,China;The First Affiliated Hospital of Henan University of Traditional Chinese Medicine,Zhengzhou 450000,Henan,China)

机构地区：[1]黄河中心医院,河南郑州450000 [2]河南中医药大学第一附属医院,河南郑州450000

出　　处：《实用中医内科杂志》2023年第3期91-94,共4页Journal of Practical Traditional Chinese Internal Medicine

基　　金：河南省科技攻关项目(182102310233)。

摘　　要：目的探讨半夏白术天麻汤加减在原发性高血压病痰湿中阻证中的治疗效果。方法采用前瞻性随机试验方法,选择2019年1月—2019年12月黄河中心医院收治的120例原发性高血压痰湿中阻证患者,依据随机数字表法分为两组各60例。对照组采用常规西药治疗,观察组在此基础上予以半夏白术天麻汤加减治疗,两组均治疗1个月,比较两组治疗前后的血压水平,治疗后的治疗效果、血压水平(收缩压[SBP]、舒张压[DBP])、血管内皮功能(内皮素-1[ET-1]、一氧化氮[NO])及炎症指标(C反应蛋白[CRP]、白细胞介素-6[IL-6]);记录并比较两组治疗期间不良反应发生率。结果治疗后,对照组治疗总有效率较观察组低(P<0.05);治疗后,两组SBP、DBP水平均较治疗前低,且观察组SBP、DBP水平均低于对照组(P<0.05);治疗后,两组ET-1、CRP、IL-6低于治疗前,NO高于治疗前,观察组ET-1、CRP、IL-6低于对照组,NO高于对照组(P<0.05);两组组治疗期间不良反应发生率比较无差异(P>0.05)。结论半夏白术天麻汤加减治疗原发性高血压病痰湿中阻证,能有效降低血压水平,改善血管内皮功能,降低炎症反应,提升治疗效果,安全性较好。Objective To explore the therapeutic effect of Banxia Baizhu Tianma Decoction on Phlegm dampness obstruction syndrome in essential hypertension.Methods 120 patients with phlegm dampness syndrome of essential hypertension treated in Huanghe Central Hospital from January to December 2019 were randomly divided into two groups with 60 cases in each group.The control group was treated with conventional western medicine,and the observation group was treated with Banxia Baizhu Tianma Decoction on this basis.Both groups were treated for 1 month.The blood pressure levels of the two groups before and after treatment,the treatment effect and blood pressure level(systolic blood pressure〔SBP〕,diastolic blood pressure〔DBP〕)after 1 month of treatment were compared Vascular endothelial function(endothelin-1〔ET-1〕,nitric oxide〔no〕)and inflammatory indexes(C-reactive protein〔CRP〕,interleukin-6〔IL-6〕);The incidence of adverse reactions during treatment was recorded and compared between the two groups.Results after one month of treatment,the total effective rate of the control group was lower than that of the observation group(P<0.05);after treatment,the levels of SBP and DBP in the two groups were lower than those before treatment,and the levels of SBP and DBP in the observation group were lower than those in the control group(P<0.05);after treatment,ET-1,CRP and IL-6 in the two groups were lower than those before treatment,and no was higher than that before treatment.ET-1,CRP and IL-6 in the observation group were lower than those in the control group,and no was higher than that in the control group(P<0.05),there was no difference in the incidence of adverse reactions between the two groups during treatment(P>0.05).Conclusion modified Banxia Baizhu Tianma Decoction in the treatment of phlegm dampness obstruction syndrome of essential hypertension can effectively reduce the blood pressure level,improve vascular endothelial function,reduce inflammatory reaction,improve the treatment effect and have good safet

关 键 词：原发性高血压病 痰湿中阻 半夏白术天麻汤 不良反应 

分 类 号：R255.3[医药卫生—中医内科学]