基于“二阳之病发心脾”探讨肠道微生物群与不孕症的关系  

The relationship between intestinal microbiota and infertility based on the theory of“the disease of double yang involve the heart and the spleen”

作　　者：郭佳易 贺丰杰 李楠 GUO Jiayi;HE Fengjie;LI Nan(Shaanxi University of Chinese Medicine,Xianyang 712046,China;Affiliated Hospital of Shaanxi University of Chinese Medicine,Xianyang 712000,China)

机构地区：[1]陕西中医药大学,咸阳712046 [2]陕西中医药大学附属医院

出　　处：《北京中医药大学学报》2023年第6期836-841,共6页Journal of Beijing University of Traditional Chinese Medicine

基　　金：国家自然科学基金项目(No.81603656);国家中医药管理局全国名老中医药专家传承工作室建设项目(No.国中医药人教函〔2022〕75号);重大疑难疾病(不孕不育)中西医临床协作试点项目。

摘　　要：近年来,不孕症的发病率持续上升,且发病人群呈年轻化趋势,如何有效地防治该疾病亦成为临床面临的难题。肠道微生物群已被证实是人体内最大的内分泌器官,其通过多种途径调控宿主的代谢,与女性的生殖内分泌密切相关。“二阳之病发心脾”理论可从中医学角度为阐述肠道微生物群与不孕症的关系提供新思路,二阳即胃肠,作为人体与外界联系的通道最易感邪致病延及心脾,二阳为腑,传化物而不藏,为心脾提供物质基础,心脾又对二阳起调控作用。因此,在心脾主导下,二阳功能协调,精血合凝,则易成胎孕。基于“二阳之病发心脾”理论阐述其与肠道微生物群、不孕症相关性的基础上,进一步阐明运用“二阳之病发心脾”理论调节机体内稳态和防治不孕症的思路,以期为不孕症的治疗提供新的理论依据和临床指导。In recent years,the prevalence of infertility has continued to rise,and the incidence in the population has shown a trend toward younger individuals,how to prevent and treat the disease more effectively has become a difficult problem.The intestinal microbiota has been shown to be the largest endocrine organ of the human.It regulates the metabolism of the host through a variety of mechanisms and is closely related to women’s reproductive endocrine functions.The theory of“the disease of double yang involve the heart and the spleen”can provide a new idea for explaining the relationship between the intestinal microbiota and infertility from the perspective of traditional Chinese medicine.The two-yang are the stomach and intestines,and as the pathway between the human body and outside world,they are susceptible to disease,including those of the heart and spleen.The stomach and intestines belong to the six fu-organs,which transport and transform water and food without storage,providing a material basis for the heart and spleen,and in turn the heart and spleen play a regulatory role in the double yang.Therefore,under the guidance of the heart and spleen,the function of double yang is coordinated,the essence and blood are combined and condensed,and pregnancy will more likely result.Based on the theory of“the disease of double yang involve the heart and the spleen”,we elaborate the correlation between the theory and intestinal microbiota and infertility,and we further elucidate the use of this theory to regulate the body's homeostasis to prevent or treat infertility,in order to provide a new theoretical basis and clinical guidance for the treatment of infertility.

关 键 词：二阳之病发心脾 肠道微生物群 不孕症 心 脾 

分 类 号：R271.14[医药卫生—中医妇科学]