疟原虫重组蛋白rVAR2及其在肿瘤靶向治疗中的应用进展  

Recombinant Malaria Protein rVAR2 and Its Application in Tumor-targeted Therapy

作　　者：蒋金露 潘海峰 于思远 李廷栋[2,3] 葛胜祥 JIANG Jin-lu;PAN Hai-feng;YU Si-yuan;LI Ting-dong;GE Sheng-xiang(School of Life Science,National Institute of Diagnostics and Vaccine Development in Infectious Disease,Xiamen University,Xiamen 361102,China;Department of Laboratory Medicine,School of Public Health,State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics,Xiamen University,Xiamen 361102,China;Collaborative Innovation Center of Biological Products,Xiamen University,Xiamen 361102,China)

机构地区：[1]厦门大学生命科学学院厦门大学国家传染病诊断试剂与疫苗工程技术研究中心,厦门361102 [2]厦门大学公共卫生学院厦门大学分子疫苗学和分子诊断学国家重点实验室,厦门361102 [3]医用生物制品省部共建协同创新中心,厦门361102

出　　处：《中国生物工程杂志》2023年第6期69-75,共7页China Biotechnology

基　　金：国家自然科学基金(31971369、82204459)资助项目。

摘　　要：恶性肿瘤是造成人类死亡的主要原因之一,其发病率和死亡率逐年上升。靶向药物可精确作用于肿瘤,在近年来备受关注。特异性识别和广泛结合肿瘤细胞是实现肿瘤靶向治疗的关键,而目前缺乏高效特异的泛肿瘤靶向工具,这极大地限制了肿瘤靶向治疗的进一步发展。与现有的肿瘤靶向方式相比,疟原虫重组蛋白rVAR2能够特异性结合肿瘤细胞表面广泛表达的癌胚硫酸软骨素(oncofetal chondroitin sulfate,ofCS),具备泛肿瘤靶向的优点,为肿瘤靶向治疗提供了新思路。对rVAR2的特点及其近年来在肿瘤靶向治疗中的应用进展进行分析和总结,并对其未来发展方向进行了展望,以期为临床肿瘤靶向治疗及诊断方法的发展提供参考。Malignant tumor is considered to be one of the main causes of human death,and its morbidity and mortality are increasing by years.Tumor-targeted drugs can act precisely on tumors and have gained a lot of attention in recent years.Specific identification and extensive binding to tumor cells are key to achieving tumortargeted therapy,and the lack of effective and specific pan-tumor targeting tools has greatly limited the further development of tumor-targeted therapy.Compared with existing tumor targeting approaches,Plasmodium recombinant protein rVAR2 can specifically bind Oncofetal chondroitin sulfate(ofCS),which is widely expressed on the surface of tumor cells,and has the advantage of pan-tumor targeting,providing a new idea for tumor targeting therapy.In this paper,we analyze and summarize the characteristics of rVAR2 and its progress in tumor-targeted therapy in recent years,and discuss its future development direction,in order to provide a reference for the development of clinical tumor-targeted therapy and diagnosis methods.

关 键 词：VAR2CSA rVAR2 硫酸软骨素癌胚硫酸软骨素肿瘤靶向 

分 类 号：Q819[生物学—生物工程]