少阳推拿法联合布地奈德雾化治疗风热型少阳体质咳嗽变异性哮喘患儿的疗效及对IL-8、IL-6、SP表达的影响研究  

Observation on the Therapeutic Effect of Shaoyang Massage Therapy Combined with Budesonide Atomization Inhalation for Children with Cough Variant Asthma of Wind-Heat Shaoyang Constitution

作　　者：石艳红 洪颖慧 黄慧思 范文萃 SHI Yan-Hong;HONG Ying-Hui;HUANG Hui-Si;FAN Wen-Cui(The Affiliated Traditional Chinese Medicine Hospital of Guangzhou Medical University,Guangzhou 510130 Guangdong,China;Guangzhou Traditional Chinese Medicine Hospital Affiliated to Guangzhou University of Chinese Medicine,Guangzhou 510130 Guangdong,China)

机构地区：[1]广州医科大学附属中医医院,广东广州510130 [2]广州中医药大学附属广州中医医院,广东广州510130

出　　处：《广州中医药大学学报》2023年第8期1989-1994,共6页Journal of Guangzhou University of Traditional Chinese Medicine

基　　金：广东省中医药局科研项目(编号:20222183);广州市荔湾区科技计划项目(编号:20221015)。

摘　　要：【目的】探讨少阳推拿法联合布地奈德雾化治疗风热型少阳体质咳嗽变异性哮喘(cough variant asthma,CVA)患儿的临床疗效及其对血清白细胞介素8(IL-8)、白细胞介素6(IL-6)、P物质(substance P,SP)表达水平的影响。【方法】将60例风热型少阳体质CVA患儿随机分为治疗组和对照组,每组各30例。对照组给予布地奈德雾化治疗,治疗组在对照组的基础上加用少阳推拿法治疗,疗程为10 d。观察2组患儿治疗前后中医证候积分及血清IL-8、IL-6、SP表达水平的变化情况,并评价2组患儿的临床疗效和安全性。【结果】(1)治疗1个疗程后,治疗组的总有效率为96.7%(29/30),对照组为83.3%(24/30),组间比较,治疗组的总有效率(χ^(2)检验)和总体疗效(秩和检验)均明显优于对照组(P<0.05)。(2)治疗后,2组患儿的咳嗽、咳痰、喘息、呼吸困难、口干口渴等中医证候积分均较治疗前明显降低(P<0.05),且治疗组对咳嗽、咳痰、喘息、呼吸困难等中医证候积分的降低作用均明显优于对照组(P<0.05)。(3)治疗后,2组患儿血清IL-8、IL-6、SP水平均较治疗前明显降低(P<0.05),且治疗组对血清IL-8、IL-6、SP水平的降低作用均明显优于对照组(P<0.05)。(4)治疗过程中,2组患儿均未发现严重不良反应,血尿常规、心电图和肝肾功能等安全性指标也均未见明显异常。【结论】少阳推拿法联合布地奈德雾化治疗风热型少阳体质CVA患儿疗效确切,可有效改善患儿的临床症状和体征,其机制可能与抑制IL-8、IL-6、SP表达,从而更好地调节免疫失衡状态有关。Objective To investigate the clinical efficacy of shaoyang massage therapy combined with Budesonide atomization inhalation for the treatment of cough variant asthma(CVA)in children with wind-heat shaoyang constitution and to observe its effect on the expression of serum interleukin 8(IL-8),interleukin 6(IL-6)and substance P(SP).Methods Sixty children with CVA of wind-heat shaoyang constitution type were randomly divided into the treatment group and the control group,with 30 cases in each group.The control group was given Budesonide atomization inhalation treatment,while the treatment group was treated with shaoyang massage therapy based on the treatment for the control group.Both groups of patients were treated for 10 days as one course of treatment.The changes in the traditional Chinese medicine(TCM)syndrome score and the expression levels of serum IL-8,IL-6 and SP in the two groups were observed before and after treatment.Meanwhile,the clinical efficacy and safety of the children in the two groups were evaluated.Results(1)After one course of treatment,the overall effective rate of the treatment group was 96.7%(29/30)and that of the control group was 83.3%(24/30),and the intergroup comparison showed that the overall effective rate(tested by Chi-square test)and overall efficacy(tested by rank sum test)of the treatment group were significantly superior to those of the control group(P<0.05).(2)After treatment,the scores of TCM symptoms of cough,expectoration,wheezing,dyspnea and dry mouth and thirst in both groups were significantly decreased compared with those before treatment(P<0.05),and the effect on decreasing the scores of cough,expectoration,wheezing and dyspnea in the treatment group was significantly superior to that in the control group(P<0.05).(3)After treatment,the serum IL-8,IL-6 and SP levels of the children in the two groups were all significantly decreased compared with those before treatment(P<0.05),and the treatment group had a significantly stronger effect on the decrease of serum IL-8,IL-6 and S

关 键 词：少阳推拿法 咳嗽变异性哮喘 风热型 少阳体质 白细胞介素8 白细胞介素6 P物质 

分 类 号：R244.1[医药卫生—针灸推拿学]