阿芬太尼联合丙泊酚用于无痛人工流产手术效果  

Efficacy and safety of afentanil combined with propofol used in painless abortion

作　　者：陈蕾蕾 葛雪鹰 李航 CHEN Leilei;GE Xueying;LI Hang(Dongyang People's Hospital,Dongyang,Zhejiang Province,322100)

机构地区：[1]浙江省东阳市人民医院,322100

出　　处：《中国计划生育学杂志》2023年第7期1591-1595,1601,共6页Chinese Journal of Family Planning

基　　金：金华市科学技术研究计划项目(2021-4-151)。

摘　　要：目的:探讨阿芬太尼联合丙泊酚用于无痛人工流产术麻醉的安全性和有效性。方法:选取2021年3月—2022年3月本院行无痛人工流产者为研究对象,采用随机、双盲法分为阿芬太尼组(阿芬太尼联合丙泊酚)和芬太尼组(芬太尼联合丙泊酚),两组各88例。观察两组静脉麻醉起效时间、麻醉过程中丙泊酚用量、意识恢复时间、出院时间,麻醉诱导前、麻醉诱导后5min、手术开始后5 min、手术完成时10 min、出手术室时心率、平均动脉压、氧饱和度变化。采用疼痛视觉模拟评分(VAS评分)评价两组给药5min及10min疼痛程度,记录两组麻醉诱导期不良反应发生情况。结果:与芬太尼组比较,阿芬太尼组静脉麻醉起效时间快(63.2±7.7s、70.6±8.7s)、麻醉过程中丙泊酚用量少(1.8±0.2 mg/kg、2.2±0.3 mg/kg)、恢复意识时间短(4.6±1.3min、6.8±2.2min)、出院时间快(38.3±4.7 min、45.4±5.2 min),咳嗽(2.3%、5.7%)、低血压(3.4%、6.8%)、恶心(5.7%、9.1%)发生率及给药5min、10min后VAS评分(4.25±1.62分、6.52±2.65分)(4.82±2.24分、7.56±1.27分)均低(均P<0.05)。血流动力学指标两组各时点均无差异(P>0.05)。结论:与芬太尼比较,阿芬太尼联合丙泊酚在无痛人工流产手术麻醉中效果更好,具有麻醉起效快、术后苏醒时间短、不良反应发生率低、住院周期短等优点,且术中血流动力学平稳,为无痛人工流产手术的麻醉提供新思路和策略。Objective:To investigate the efficacy and safety of afentanil combined with propofol used in painless abor-tion.Methods:The women who planned to undergo painless abortion in hospital were selected as the research objects from March 1,2022 to March 1,2022.These women were randomly divided into experimental group(women with al-fentanil combined with propofol for anesthesia)and control group(women with fentanyl combined with propofol for anesthesia).The onset time of intravenous anesthesia,the dosage of propofol used during anesthesia,the time of con-sciousness recovery,and the time of discharge of the women in the two groups were observed.The changes of the values of heart rate(P),mean arterial pressure(MAP),and oxygen saturation(SpO2)of the women in the two groups before anesthesia induction(T0),5 min after anesthesia induction(T1),5 min after the beginning of surgery(T2),10 min after the completion of surgery(T3),and when leaving the operating room(T4)were observed.The visual an-alogue scale(VAS)score was used to evaluate the degree of pain of the women in the two groups at 5 min and 10 min after administration.The adverse reactions during the induction period of anesthesia of the women in the two groups.were recorded during the anesthesia induction.Results:The onset time of intravenous anesthesia(63.2±7.7s)of the women in group A was significantly faster than that(70.6±8.7s)of the women in group B.The dosage of propofol used during anesthesia(1.8±0.2 mg/kg)of the women in group A was significantly lower than that(2.2±0.3 mg/kg)of the women in group B.The time of the consciousness recovery(4.6±1.3min)of the women in group A was significantly shorter than that(6.8±2.2min)of the women in group B.The time to discharge from hospital(38.3±4.7 min)of the women in group A was significantly less than that(45.4±5.2 min)of the women in group B.The inci-dences of cough(2.3%),hypotension(3.4%),and nausea(5.7%)of the women in group A were significantly lower than those(5.7%,6.8%,and 9.1%)of the women in group B.The VA

关 键 词：无痛人工流产术 阿芬太尼 丙泊酚 有效性 

分 类 号：R169.42[医药卫生—公共卫生与预防医学]