Finkler超声评分、全身免疫炎症指数联合血清CA125对老年卵巢癌诊断和化疗疗效评估  

Values of Finkler ultrasound score and the systemic immune inflammation index and the serum carbohydrate antigen 125 levels of elderly patients for diagnosing their ovarian cancer and the chemotherapy efficacy evaluation of the patient

作　　者：王云香[1] 顾亮亮[1] 王建锋[1] 董璞 WANG Yunxiang;GU Liangliang;WANG Jianfeng;DONG Pu(Nanyang Central Hospital,Nanyang,Henan Province,473000)

机构地区：[1]河南省南阳市中心医院,473000

出　　处：《中国计划生育学杂志》2023年第7期1612-1617,共6页Chinese Journal of Family Planning

摘　　要：目的:评估Finkler超声评分、全身免疫炎症指数(SII)联合血清糖类抗原125(CA125)对老年卵巢癌诊断和化疗疗效临床价值。方法:收集本院2017年1月—2021年3月120例老年卵巢癌患者为卵巢癌组,卵巢良性肿瘤患者60例为良性肿瘤组,两组均在治疗前行彩色多普勒超声检查,检测SII及CA125。根据卵巢癌患者首次化疗结束后无瘤生存期分为化疗反应组和无反应组。以受试者工作特征曲线(ROC)分析各指标诊断效能。以logistic回归分析影响卵巢癌化疗反应的危险因素。结果:卵巢癌组Finkler超声评分(7.61±1.40分)及阳性率(76.7%)、SII(269.91±37.67)、CA125(284.44±38.40 U/ml)均高于良性肿瘤组(5.70±1.78分、10.0%、199.34±41.27、118.41±90.72 U/ml)(均P<0.05)。Finkler超声评分、SII、CA125及其联合应用均可用于鉴别诊断卵巢良恶性病变,且联合诊断的敏感度(91.3%)、特异性(93.3%)最高。卵巢癌患者均接受化疗,24个月随访,无瘤生存期(DFS)≥6个月为反应组71例、无反应组49例,与反应组比,无反应组临床分期III~IV占比、Finkler超声评分、SII和CA125均较高(P<0.05)。logistic分析显示,临床分期和CA125水平升高是影响老年卵巢癌化疗反应的独立危险因素(P<0.05);死亡36例(30.0%),存活84例(70.0%),死亡组CA125水平高于存活组(P<0.05)。结论:Finkler超声评分、SII和CA125联合检测鉴别诊断卵巢良恶性病变效能较高,临床分期和CA125是影响化疗反应的危险因素,CA125水平较高者降低2年存活率。Objective:To investigate the values of Finkler ultrasound score,and systemic immune inflammation index(SII)and serum carbohydrate antigen 125(CA125)levels of elderly patients for diagnosing their ovarian cancer,and to study the chemotherapy efficacy evaluation of the patients.Methods:120elderly patients with ovarian cancer were included in study group,and 60patients with benign ovarian tumors were included in control group from January 2017to March 2021.All the patients were examined by color Doppler ultrasound,and their SII and CA125levels was detected before treatment.According to the duration of the tumor free survival of the patients in the study after the first chemotherapy,the patients were divided into group A(the patients with chemotherapy response)and group B(the patients without chemotherapy response).The diagnostic efficiencies of Finkler ultrasound score,and the SII and serum CA125 levels of the patients for their ovarian cancer were evaluated by receiver operating characteristic curve(ROC).Logistic regression analysis was used to identify the risk factors affecting the chemotherapy efficacy for threating the ovarian cancer of the patients.Results:Finkler ultrasound score,and the levels of SII and CA125of the patients in the study group were significantly higher than those of the patients in the control group(all P<0.05).Finkler ultrasound score,the SII level,and the CA125level,and the combination of Finkler ultrasound score and the SII and CA125levels could be used for differential diagnosis of the benign and the malignant ovarian lesions of the patients.The combination of Finkler ultrasound score and the SII and CA125levels of the patients had the highest sensitivity(91.3%)and the highest specificity(93.3%).After 24months of follow-up,there were 71patients in group A and 49patients in group B with disease free survival(DFS)≥6months.The proportion of III-IV clinical stage of the ovarian cancer,the Finkler ultrasound score,the SII and CA125levels of the patients in group B were significantly higher

关 键 词：老年卵巢癌 Finkler超声评分 全身免疫炎症指数 糖类抗原125 化疗疗效 分期 预后 影响因素 

分 类 号：R737.31[医药卫生—肿瘤]