子痫前期孕妇血浆ADP、HCY水平与胎儿宫内生长发育关系  

Correlation between the plasma adiponectin and homocysteine levels of pregnant women with preeclampsia and their fetal growth and development

作　　者：黎灵萍 李浩 赵庆珠 苏翠珍 LI Lingping;LI Hao;ZHAO Qingzhu;SU Cuizhen(Sanya Traditional Chinese Medicine Hospital,Sanya,Hainan Province,572000;The First Affiliated Hospitalof Hainan Medical College;HaiKou Hospital Affiliated to Xiangya School of Medicine,Central South University;Sanya People's Hospita)

机构地区：[1]海南省三亚市中医院,572000 [2]海南医学院第一附属医院 [3]中南大学湘雅医学院附属海口医院 [4]海南省三亚市人民医院

出　　处：《中国计划生育学杂志》2023年第7期1689-1693,共5页Chinese Journal of Family Planning

基　　金：海南省卫生健康行业科研项目(20A200040)。

摘　　要：目的:探讨子痫前期孕妇血浆脂联素(ADP)、同型半胱氨酸(HCY)水平及与胎儿宫内生长发育关系。方法:回顾性收集2019年1月—2020年12月本院收治的子痫前期孕妇126例,根据分娩后胎儿的胎龄以及出生体质量分为小于胎龄儿(SGA)组30例、适于胎龄儿(AGA)组71例和大于胎龄儿(LGA)组25例;选取42例分娩健康AGA胎儿孕妇为健康对照组。孕妇均于妊娠晚期检测血浆ADP、HCY,胎儿分娩后测量出生身长、出生体质量、出生头围。分析子痫前期孕妇血浆ADP、HCY水平与胎儿生长参数的相关性。采用logistic回归分析胎儿宫内发育迟缓的影响因素。结果:SGA组胎儿的出生身长、出生体质量、出生头围均小于另外3组,血浆ADP水平低于另外3组,血浆HCY水平高于另外3组(均P<0.05)。子痫前期孕妇胎儿出生身长、出生体质量、出生头围与孕妇血浆ADP水平呈正相关,与血浆HCY水平呈负相关(P<0.05)。血浆ADP高水平是胎儿宫内发育迟缓的保护性因素(OR=0.386),血浆HCY高水平是胎儿宫内发育迟缓的危险因素(OR=4.063)。结论:子痫前期孕妇血浆ADP、HCY水平异常,且与胎儿宫内生长发育密切相关,HCY高水平、ADP低水平可能增加胎儿宫内发育迟缓的风险。Objective:To investigate the correlation between the plasma adiponectin(ADP)and homocysteine(HCY)levels of pregnant women with preeclampsia and their fetal growth and development.Methods:126pregnant women with preeclampsia between January 2019and December 2020were collected retrospectively.According to the fetal gestational weeks when born and the neonatal birth weight,these women were divided 30women with neonatal small for gestational age(SGA)in group A,71women with neonatal appropriate for gestational age(AGA)in group B,and 25 women with neonatal large for gestational age(LGA)in group C.Meanwhile,42healthy pregnant women with the healthy AGA fetus were selected in group D.The levels of plasma ADP and HCY of the women during the third trimester of pregnancy in the four groups were tested.The neonatal birth height,birth weight,and birth head circumference of the neonates in the four groups were measured after born.The correlation between the plasma ADP and HCY levels of the women with preeclampsia and their neonatal growth parameters values was analyzed.Logistic regression analysis was used to analyze the factors influencing fetal intrauterine growth retardation.Results:The birth length,birth weight,and birth head circumference of the neonates in group A were significantly lower than those of the neonates in the other three groups,the plasma ADP level of the neonates in group A was significantly lower,and the plasma HCY level of the neonates in group A was significantly higher(all P<0.05).The birth length,birth weight,and birth head circumference of the neonates of the pregnant women with preeclampsia were positively correlated with their plasma ADP level,and were negatively correlated with their plasma HCY level(P<0.05).The high plasma ADP level of the women was a protective factor for their fetal intrauterine growth retardation(OR=0.386),but the high plasma HCY level was a risk factor for their fetal intrauterine growth retardation(OR=4.063).Conclusion:The levels of ADP and HCY of the pregnant women with preec

关 键 词：子痫前期 脂联素 同型半胱氨酸 胎儿宫内发育迟缓 相关性 

分 类 号：R714.244[医药卫生—妇产科学] R714.5[医药卫生—临床医学]