龙牙楤木化学成分与药理作用研究进展  

Progress in Research on Chemical Constituents and Pharmacological Action of Aralia elata

作　　者：牟俊宇 李兰芳 马秋晓 王敏[2] 叶景学[2] 于蕾[1] 孙桂波[2] MU Jun-yu;LI Lan-fang;MA Qiu-xiao;WANG Min;YE Jing-xue;YU Lei;SUN Gui-bo(Research Center of Pharmaceutical Engineering Technology,Harbin University of Commerce,Harbin 150076,China;Institute of Medicinal Plant Development,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing Key Laboratory of Innovative Drug Research and Development of Traditional Chinese Medicine(Natural Medicine),Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine,Ministry of Education,Beijing 100193,China)

机构地区：[1]哈尔滨商业大学药物工程研究中心,哈尔滨150076 [2]中国医学科学院北京协和医学院药用植物研究所,中药(天然药物)创新药物研发北京市重点实验室,中草药生物活性物质与资源利用教育部重点实验室,北京100193

出　　处：《中国药学杂志》2023年第10期856-864,共9页Chinese Pharmaceutical Journal

基　　金：国家自然科学基金项目资助(81973514);黑龙江省自然科学基金项目联合引导项目资助(LH2020H070);哈尔滨商业大学2021教师创新项目支持计划(LH2020H070)。

摘　　要：龙牙楤木是五加科楤木属植物,在我国有着悠久的使用历史,广泛用于治疗肝炎、风湿性关节炎等多种疾病。龙牙楤木的化学成分多样,包括三萜皂苷、多糖类、甾体及其苷类、生物碱、氨基酸、挥发油等,其中研究最多的是皂苷类和多糖类成分,具有抗炎、抗氧化、抗肿瘤、保护心脏、保肝护肝等作用。笔者综述了龙牙楤木的化学成分及药理作用研究进展,并对该植物的潜在药用价值和研究不足之处展开讨论,以期为其进一步开发利用提供参考依据。Aralia elata is a traditional Chinese medicine with a long history of medicinal use.It is widely used in the treatment of various diseases.The main active components of Aralia elata are saponins and polysaccharides.It has anti-inflammatory,antioxidant,anti-tumor,heart protection,liver protection,and other functions.Since the last century,the research of Aralia elata has gradually delved into its specific chemical composition.This review introduced the considerable diversity of pharmacological effects of Aralia elata reported in numerous articles published in China and other countries and summarized the research progress of its chemical constituents,focusing on saponins and polysaccharides of monomers.The potential medicinal value of this plant and the shortcomings of current research were also discussed.It is hoped that this review will help expand the application of this high-value medicinal plant in drug therapy and further discover new drugs based on the active ingredients and secondary metabolites of this plant.

关 键 词：龙牙楤木 龙牙楤木皂苷 龙牙楤木多糖 心血管 药理作用 

分 类 号：R966[医药卫生—药理学]