3D-assembled microneedle ion sensor-based wearable system for the transdermal monitoring of physiological ion fluctuations  

作　　者：Xinshuo Huang Shantao Zheng Baoming Liang Mengyi He Feifei Wu Jingbo Yang Hui-jiuan Chen Xi Xie 

机构地区：[1]State Key Laboratory of Optoelectronic Materials and Technologies,School of Electronics and Information Technology,Guangdong Province Key Laboratory of Display Material and Technology,Sun Yat-Sen University,Guangzhou,China [2]Pazhou Lab,510330 Guangzhou,China [3]School of Biomedical Engineering,Sun Yat-Sen University,Guangzhou,China

出　　处：《Microsystems & Nanoengineering》2023年第2期127-142,共16页微系统与纳米工程（英文）

基　　金：support from the National Key R&D Program of China(Grant No.2021YFF1200700,2021YFA0911100);National Natural Science Foundation of China(Grant No.32171399,32171456,T2225010);Guangdong Basic and Applied Basic Research Foundation(Grant No.2021A1515012261);Science and Technology Program of Guangzhou,China(Grant No.202103000076);Fundamental Research Funds for the Central Universities,Sun Yat-Sen University(Grant No.22dfx02);Pazhou Lab,Guangzhou(Grant No.PZL2021KF0003);Opening Project of Key Laboratory of Microelectronic Devices&Integrated Technology,Institute of Microelectronics,Chinese Academy of Sciences,Tianjin Key Laboratory of Imaging and Sensing Microelectronic Technology,Key Laboratory of The Diagnosis and Treatment of Severe Trauma and Burn of Zhejiang Province,Second Affliated Hospital of Zhejang University,School of Medicine(Grant.2022K02);State Key Laboratory Of Precision Measuring Technology And Instruments(Grant No.pilab2211);Open Funds of State Key Laboratory of Oncology in South China(Grant No.HN2022-01).

摘　　要：Monitoring human health is of considerable significance in biomedicine.In particular,the ion concentrations in blood are important reference indicators related to many diseases.Microneedle array-based sensors have enabled promising breakthroughs in continuous health monitoring due to their minimally invasive nature.In this study,we developed a microneedle sensing-array integrated system to continuously detect subcutaneous ions to monitor human health status in real time based on a fabrication strategy for assembling planar microneedle sheets to form 3D microneedle arrays.The limitations of preparing 3D microneedle structures with multiple electrode channels were addressed by assembling planar microneedle sheets fabricated via laser micromachining;the challenges of modifying closely spaced microneedle tips into different functionalized types of electrodes were avoided.The microneedle sensing system was sufficiently sensitive for detecting real-time changes in Ca^(2+),K^(+),and Na^(+) concentrations,and it exhibited good detection performance.The in vivo results showed that the ion-sensing microneedle array successfully monitored the fluctuations in Ca^(2+),k^(+),and Na^(+) in the interstitial fluids of rats in real time.By using an integrated circuit design,we constructed the proposed microneedle sensor into a wearable integrated monitoring system.The integrated system could potentially provide information feedback for diseases related to physiological ion changes.

关 键 词：needle SYSTEM BREAKTHROUGH 

分 类 号：TP212[自动化与计算机技术—检测技术与自动化装置] TB383[自动化与计算机技术—控制科学与工程]