腹主动脉瘤的危险因素及与脂联素基因多态性的相关性分析  

Analysis of risk factors of abdominal aortic aneurysm and its correlation with adiponectin gene polymorphism

作　　者：吴忠隐 刘双庆[2] 张弘[1] 卫任[3] 熊江[3] Wu Zhongyin;Liu Shuangqing;Zhang Hong;Wei Ren;Xiong Jiong(Department of Vascular Surgery,Affiliated Hospital of Chengde Medical University,Chengde 067000,China;Department of Emergency,Affiliated Hospital of Chengde Medical University,Chengde 067000,China;Department of Vascular Surgery,The First Medical Center of Chinese PLA General Hospital,Beijing 100853,China)

机构地区：[1]承德医学院附属医院血管普外科,河北承德067000 [2]承德医学院附属医院急诊科,河北承德067000 [3]解放军总医院第一医学中心血管外科,北京100853

出　　处：《中国血管外科杂志（电子版）》2023年第2期153-157,共5页Chinese Journal of Vascular Surgery(Electronic Version)

基　　金：河北省医学科学研究课题计划项目(20200363)。

摘　　要：目的 探讨腹主动脉瘤(abdominal aortic aneurysm,AAA)发生的危险因素以及与脂联素+276G/T的相关性。方法 采用病例对照研究设计纳入2011年7月至2021年12月于解放军总医院第一医学中心就诊的155例AAA患者为病例组,按照年龄、性别配对条件同期纳入310例非AAA患者为对照组。采用质谱分析法测定DNA样本脂联素+276G/T位点,回归分析法探讨基因型和AAA的关系。结果 吸烟(OR=4.088,95%CI=2.297~7.275,P<0.001)、高血压(OR=2.105,95%CI=1.331~3.327,P=0.001)、外周动脉疾病(OR=2.328,95%CI=1.399~3.874,P=0.001)、血脂异常(OR=2.673,95%CI=1.651~4.328,P<0.001)是AAA发生的危险因素。病例组患者与对照组的脂联素+276G/T基因型分布差异无统计学意义(P>0.05)。脂联素+276G/T基因型频率在大、小AAA组间的分布差异无统计学意义(P>0.05)。结论 AAA发生受高脂血症、吸烟、高血压、外周动脉疾病等多种因素影响,暂未发现AAA与脂联素+276G/T有明显相关性。Objective To investigate the risk factor of abdominal aortic aneurysm(AAA)and its correlation with+276 G/T polymorphisms of the adiponectin gene.Methods A case-control study was designed,155 patients with AAA who visited the First Medical Center of Chinese PLA General Hospital from July 2011 to December 2021 were included as the case group,and 310 patients without AAA were included as the control group according to age and gender matching conditions during the same period.Mass spectrometry was used to measure the adiponectin+276G/T site in DNA samples.The relationship between genotype and AAA was explored by regression analysis.Results Smoking(OR=4.088,95%CI=2.297-7.275,P<0.001),hypertension(OR=2.105,95%CI=1.331-3.327,P=0.001),peripheral arterial disease(OR=2.328,95%CI=1.399-3.874,P=0.001)and dyslipidemia(OR=2.673,95%CI=1.651-4.328,P<0.001)were risk factors of AAA.There was no significant difference in the distribution of adiponectin+276G/T genotype between the case group and the control group(P>0.05).There was also no significant difference in the distribution of adiponectin+276G/T genotype frequency between large and small AAA groups(P>0.05).Conclusion The occurrence of AAA is affected by many factors such as hyperlipidemia,smoking,hypertension.There is no significant correlation between polymorphism of+276 G/T of the adiponectin gene and AAA.

关 键 词：腹主动脉瘤 脂联素 基因 单核苷酸多态性 危险因素 

分 类 号：R543.1[医药卫生—心血管疾病]