新型冠状病毒肺炎伴皮疹患者的初步临床调查分析  

Investigation and analysis of patients with COVID-19 and skin rashes

作　　者：汪莹 李佳欣 杨秀敏[1] 魏爱华[1] WANG Ying;LI Jia-xin;YANG Xiu-min(Department of Dermatology,Beijing Tongren Hospital,Capital Medical University,Beijing 100730,China)

机构地区：[1]首都医科大学附属北京同仁医院皮肤科,北京100730

出　　处：《临床和实验医学杂志》2023年第12期1339-1342,共4页Journal of Clinical and Experimental Medicine

基　　金：国家自然科学基金面上项目(编号:82173447)。

摘　　要：目的观察新型冠状病毒肺炎(COVID-19)伴皮疹患者的皮损表现类型、持续时间、相关实验室检查及伴随症状。方法回顾性收集2022年12月至2023年4月因COVID-19伴皮疹就诊首都医科大学附属北京同仁医院门诊的38例患者,详细询问病史和查体、留取皮损处大体照片和皮肤镜照片、采集外周血行实验室检查。4周后就皮疹转归情况进行电话随访。结果38例患者完成全部临床调查。皮损分别表现为红斑19例(50.0%),荨麻疹16例(42.1%),瘀斑2例(5.3%),水疱样皮损1例(2.6%)。患者在出现COVID-19全身症状后平均3.9 d出现皮肤损害,皮疹平均持续5.2 d。12例(31.6%)患者红细胞沉降率增加,7例(18.4%)患者C-反应蛋白升高,5例(13.1%)患者血小板计数异常(5例升高,2例降低),6例(17.6%)患者血清总IgE升高,8例(21.1%)患者中性粒细胞计数增加。结论COVID-19伴皮疹的患者,皮损类型多表现为红斑型及荨麻疹样,实验室检查观察到部分患者ESR、CRP、NEUT增高及PLT计数异常。Objective To observe the type of skin lesions,duration,relevant laboratory tests and accompanying symptoms of patients with corona virus disease 2019(COVID-19)and skin rashes.Methods From December 2022 to April 2023,a total of 38 patients who visited the outpatient clinic of Beijing Tongren Hospital,Capital Medical University due to COVID-19 and skin rashes were retrospectively collected.Their medical history was inquired and examined in detail,and gross and dermatoscopic photos of skin lesions and peripheral blood were collected for laboratory examination.After 4 weeks,a telephone follow-up was conducted to assess the outcome of the rash.Results There were 38 patients completed data collection and follow-up by telephone.Among them,19(50.0%)patients showed erythematous lesions,16(42.1%)patients showed urticaria-like lesions,2(5.3%)patient showed ecchymosis,and 1(2.6%)patient showed blister-like lesions.The average duration of the rash was 5.2 days,and the patients had skin damage 3.9 days after the onset of systemic symptoms of COVID-19 infection.12(31.6%)patients had an increase in erythrocyte sedimentation rate,7(18.4%)patients had an increase in C-reactive protein,33(86.9%)patients had a normal platelet count,6(17.6%)patients tested for IgE reported an increase and 8(21.1%)patients had an increase in neutrophil count.Conclusion The skin lesions of patients with COVID-19 and skin rashes were mostly erythema type and urticaria type.Laboratory examination showed that ESR,CRP and neutrophil count increased in some patients.

关 键 词：COVID-19 皮疹 实验室检查 

分 类 号：R563.1[医药卫生—呼吸系统]