In vitro cell stretching devices and their applications:From cardiomyogenic differentiation to tissue engineering  

作　　者：Jiangtao Zhao Fanzhe Meng Jiayi Qian Yan Huang Yubo Fan 

机构地区：[1]Key Laboratory of Biomechanics and Mechanobiology(Beihang University),Ministry of Education,Beijing Advanced Innovation Center for Biomedical Engineering,School of Biological Science and Medical Engineering,Beihang University,Beijing,100083,China [2]School of Engineering Medicine,Beihang University,Beijing,100083,China

出　　处：《Medicine in Novel Technology and Devices》2023年第2期1-12,共12页医学中新技术与新装备（英文）

基　　金：This work was supported by the National Natural Science Foundation of China(Nos.U20A20390,11827803,and 11302020);the 111 Project(No.B13003).

摘　　要：Mechanical stretch plays an important role in the control of cardiomyocyte behavior,as well as in the study of the mechanisms of cardiovascular function and pathology.The complexity involved in biological systems in vivo has created a need for better in vitro techniques,thus a variety of cell stretching devices have been developed for a deeper understanding of cellular responses to strain.In this review,we introduce the design,functionality,and characteristics of multiple types of cell stretching devices from two and three dimensions,then discuss the research progress of promoting cardiomyogenic differentiation of stem cells by external stretching and its application in cardiac tissue engineering.

关 键 词：Mechanical stretch in vitro devices Stem cell Cardiomyogenic differentiation HYDROGELS 

分 类 号：R318[医药卫生—生物医学工程]