外泌体在感音神经性聋中的作用研究进展  

Research progress in the role of exosomes in sensorineural hearing loss

作　　者：孟雨 王雪[1,2] 陈放 路钧泽 王嫚 刘闻闻[1,2] MENG Yu;WANG Xue;CHEN Fang;LU Jun-ze;WANG Man;LIU Wen-wen(Department of Otolaryngology-Head and Neck Surgery,Shandong Provincial ENT Hospital,Shandong University,Jinan 250022,China;Shandong Institute of Otorhinolaryngology,Jinan 250022,China)

机构地区：[1]山东省耳鼻喉医院耳鼻咽喉头颈外科,山东大学,山东济南250022 [2]山东省耳鼻喉研究所,山东济南250022

出　　处：《实用医院临床杂志》2023年第4期12-15,共4页Practical Journal of Clinical Medicine

基　　金：国家自然科学基金资助项目(编号:82271176);山东省自然科学基金重大基础项目(编号:ZR2020ZD39)。

摘　　要：感音神经性聋是一种常见的致残性内耳疾病,由于耳蜗、听神经或听觉中枢部位产生病变引起,具有不可逆性,目前尚无法通过药物治疗。外泌体是细胞主动分泌到胞外的具有生物活性的纳米级双层脂质囊泡,包括多种特异性蛋白质、脂质和核酸,靶向作用于受体细胞,参与细胞间信息交流。研究发现,外泌体可能参与听觉细胞间物质传递及信息交流。本文综述外泌体在感音神经性聋发生发展中的作用和潜在临床应用价值的相关研究进展。Sensorineural hearing loss(SNHL)is a common disabling disease.It is caused by a lesion in the cochlea,auditory nerve or the auditory center in brain.SNHL is irreversible.There is currently no medical treatment.Exosomes are biologically active nano-scale double-layered lipid vesicles that are actively secreted by cells.They include a variety of specific proteins,lipids,and nucleic acids.They target the recipient cells and participate in the exchange of information between cells.It has been found that exosomes might be involved in material transmission and information exchange between auditory cells.This article reviews research progress on the role of exosomes in SNHL and its potential clinical application.

关 键 词：感音神经性聋 外泌体 生物标志物 内耳治疗 

分 类 号：R764[医药卫生—耳鼻咽喉科]