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作 者:郑莎莎 崔庆悦 齐艳茹 程红 魏浩 胡扬楠 柴人杰 ZHENG Sha-sha;CUI Qing-yue;QI Yan-ru;CHENG Hong;WEI Hao;HU Yang-nan;CHAI Ren-jie(State Key Laboratory of Digital medical Engineering,Department of Otolaryngology,Head and Neck Surgery,Zhongda Hospital,School of Life Sciences and Technology,Advanced Institute for Life and Health,Jiangsu Provincial High-Tech Key Laboratory for Bio-Medical Research,Southeast University,Nanjing 210096,China;Co-Innovation Center of Neuroregeneration,Nantong University,Nantong 226001,China;Department of Otolaryngology,Head and Neck Surgery,Affiliated Drum Tower Hospital of Nanjing University Medical School,Nanjing 210008,China;Department of Otolaryngology,Head and Neck Surgery,Sichuan Academy of Medical Sciences&Sichuan Provincial People′s Hospital,Chengdu 610072,China;Institute for Stem Cell and Regeneration,Chinese Academy of Science,Beijing 100101,China;Beijing Key Laboratory of Neural Regeneration and Repair,Capital Medical University,Beijing 100069,China)
机构地区:[1]东南大学数字医学工程全国重点实验室,附属中大医院耳鼻咽喉头颈外科,生命科学与技术学院,生命健康高等研究院,江苏省生物医药高新技术研究重点实验室,江苏南京210096 [2]南通大学神经再生协同创新中心,江苏南通226001 [3]南京大学医学院附属鼓楼医院耳鼻咽喉头颈外科,江苏南京210008 [4]四川省医学科学院·四川省人民医院耳鼻咽喉头颈外科,四川成都610072 [5]中国科学院干细胞与再生医学研究中心,北京100101 [6]首都医科大学北京市神经再生修复研究重点实验室,北京100069
出 处:《实用医院临床杂志》2023年第4期19-23,共5页Practical Journal of Clinical Medicine
基 金:国家重点研发计划(编号:2021YFA1101300,2020YFA0112503);国家自然科学基金重点项目和面上项目(编号:82030029,81970882)。
摘 要:耳聋已成为影响社会政治和经济的全球性健康问题,其中感音神经性聋是最常见的耳聋形式。导致感音神经性聋的途径和机制多样,其中螺旋神经元的神经突退化和丧失是造成感音神经性聋的核心原因。随着生物医学工程技术的飞速发展,构建能够模拟螺旋神经元组织生长微环境的仿生支架来诱导其生长,是实现螺旋神经元再生的关键步骤。本文系统回顾和总结了通过仿生支架和电刺激等诱导螺旋神经元再生的研究进展,并讨论了未来潜在的治疗方法。Deafness has become a global health issue that affects sociopolitics and economy,and sensorineural hearing loss is the most common form of deafness.There are various pathways and mechanisms leading to sensorineural hearing loss.Among them,the degeneration and loss of neurites of spiral neurons is the core cause of sensorineural hearing loss.With the rapid development of biomedical engineering technology,it is possible to construct biomimetic scaffold to simulate the microenvironment of spiral ganglion neurons tissue growth,thus,to induce their growth.This is a key step to achieve the regeneration of spiral ganglion neurons.In this paper,we review and summarize the research progress on the induction of spiral neuron regeneration through biomimetic scaffolds and electrical stimulation.The potential future therapeutic methods are also discussed.
关 键 词:感音神经性耳聋 螺旋神经元再生 仿生支架 电刺激
分 类 号:R764[医药卫生—耳鼻咽喉科]
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