顺铂耳毒性:毛细胞死亡的分子机制及潜在靶点  

Cisplatinototoxicity:molecular mechanisms and potential targets of hair cell death

作　　者：万应翠 万珮峰 柴人杰 付小龙 孙锦 WAN Ying-cui;WAN Pei-feng;CHAI Ren-jie;FU Xiao-long;SUN jin(Shandong First Medical University,Jinan 250117,China;Shandong University,Qingdao 266237,China;Southeast University,Nanjing 211189,China)

机构地区：[1]山东第一医科大学,山东济南250117 [2]山东大学,山东青岛266237 [3]东南大学,江苏南京211189

出　　处：《实用医院临床杂志》2023年第4期35-39,共5页Practical Journal of Clinical Medicine

基　　金：国家自然科学基金面上项目(编号:82271175)。

摘　　要：顺铂治疗过程中会引起严重的耳毒性副作用,其诱导的听力损失通常伴随着内耳感觉毛细胞的死亡;毛细胞在维持听力方面发挥着重要作用。了解顺铂诱导毛细胞死亡的分子机制以及针对相应靶点进行治疗是十分必要的。本文就顺铂诱导毛细胞死亡方式的分子机制和最新耳毒性保护措施进展进行报道。Cisplatin can also cause serious ototoxic side effects during treatment.Cisplatin-induced hearing loss is usually accompanied by the death of inner ear sensory hair cells.The hair cells play an important role in maintaining hearing.It is essential to understand the molecular mechanisms of cisplatin-induced hair cell death and develop the targeted therapies for corresponding targets.This paper reports on the molecular mechanisms of cisplatin-induced hair cell death and the latest development in ototoxicity protective measures.

关 键 词：顺铂 耳毒性 细胞凋亡 细胞焦亡 铁死亡 

分 类 号：R764[医药卫生—耳鼻咽喉科]