益肺祛毒法治疗肺癌的真实世界生存分析  

Effects of the method of benefiting the lung and removing toxins on the survival of patients with primary lung cancer based on the real-world research method

作　　者：李君维 李荣华[2] Li Junwei;Li Ronghua(College of Traditional Chinese Medicine,Chongqing Medical University,Chongqing 400010,China;Department of Oncology,Beibei Hospital of Traditional Chinese Medicine,Chongqing 400700,China)

机构地区：[1]重庆医科大学中医药学院,重庆400010 [2]重庆市北碚区中医院肿瘤科,重庆400700

出　　处：《吉林中医药》2023年第7期821-824,共4页Jilin Journal of Chinese Medicine

基　　金：重庆市科卫联合中医药技术创新与应用发展项目(2020ZY023916);全国中医药创新骨干人才培训项目。

摘　　要：目的研究益肺祛毒法对原发性肺癌患者生存率及生存时间的影响。方法采用真实世界研究方法,回顾性分析1042例原发性肺癌患者的临床资料,按照治疗方案分为益肺祛毒组190例和对照组852例。结果益肺祛毒组1、2、3、5生存率分别为81.57%、43.68%、23.68%、11.05%,MST为44.26个月,明显优于对照组。单因素分析显示患者生存期与治疗方案分组(P=0.000)、性别(P=0.000)、年龄(P=0.000)、病理类型(P=0.000)、临床分期(P=0.000)相关;COX回归模型多因素分析显示益肺祛毒法可能是患者预后生存期的独立保护因子。结论益肺祛毒法在益气养阴的同时,清热、化痰、攻窜、软坚四法合用祛毒攻癌,有助于延长原发性肺癌患者的生存期。Objective To study the effects of the method of benefiting the lung and removing toxins(BLET)on the survival rate and survival time of patients with primary lung cancer.Methods A total of 1,042 patients with primary lung cancer were divided into a BLET group(190 cases)and a control group(852 cases)according to their different treatment regimens,and their clinical data were retrospectively analyzed by the real-world research method.Results The survival rates of the BLET group for one,two,there and five years were 81.57%,43.68%,23.68%,and 11.05%,respectively,and its MST was 44.26 months,which were all significantly better than those in the control group.A univariate analysis showed that the survival time of patients was correlated with the treatment plan(P=0.000),gender(P=0.000),age(P=0.000),pathological type(P=0.000)and clinical stage(P=0.000).A multivariate analysis of COX regression model showed that the method of benefiting the lung and removing toxins might be an independent protective factor affecting their prognosis and survival.Conclusion While benefiting qi and nourishing yin,the BLET method can be combined with the four methods of clearing heat,resolving phlegm,dispelling toxins and softening hard masses to treat cancer,which helps to prolong the survival period of patients with primary lung cancer.

关 键 词：原发性肺癌 中医药 益肺祛毒法 真实世界 生存分析 

分 类 号：R256.1[医药卫生—中医内科学]