胆道菌群与原发性肝内胆管结石形成的研究进展  

Progress on biliary flora and primary intrahepatic stone formation

作　　者：兰华 高丽莎 罗莹 张铭光[1] LAN Hua;GAO Lisha;LUO Ying;ZHANG Mingguang(Department of Gastroenterology,West China Hospital,Sichuan University,Chengdu,Sichuan 610000,China)

机构地区：[1]四川大学华西医院消化内科,四川成都610000

出　　处：《公共卫生与预防医学》2023年第4期119-123,共5页Journal of Public Health and Preventive Medicine

摘　　要：原发性肝内胆管结石(primary intrahepatic stones,PIS)是肝胆外科难治性疾病之一,也是造成良性胆道疾病死亡的重要病因,其在我国长江流域以及东南沿海地区有较高的患病率。目前关于PIS发生机制并未完全阐明,但胆道菌群在PIS形成中的作用已得到越来越多研究认可。此文就胆道菌群在PIS形成中的研究进展展开综述,以期加强临床对PIS发生机制认识,并提高对胆道菌群检测的重视,从而为PIS防治及预后改善等提供参考。Primary intrahepatic stone(PIS)is one of the intractable diseases in hepatobiliary surgery and an important cause of death from benign biliary tract diseases,and it has a high prevalence in the Yangtze River basin and southeastern coastal areas of China.At present,the mechanism of PIS occurrence has not been fully elucidated,but the role of biliary flora in the formation of PIS has been recognized by more and more studies.This article reviews the research progress of biliary flora in the formation of PIS with a view to strengthening the clinical understanding of mechanism of PIS,increasing the attention to the detection of biliary flora,and providing a reference for the prevention and treatment of PIS and the improvement of prognosis.

关 键 词：原发性肝内胆管结石 胆道菌群 细菌谱 致病机制 

分 类 号：R181[医药卫生—流行病学]