心脏运动康复对急性心肌梗死PCI术后患者心功能及血清apoE、apoB水平的影响  

Effects of cardiac exercise rehabilitation on cardiac function and serum apoE and apoB levels in patients with acute myocardial infarction after PCI

作　　者：冯旭霞 王文静[1] 吴文虎 崔小红[1] 尹培永 FENG Xuxia;WANG Wenjing;WU Wenhu;CUI Xiaohong;YIN Peiyong(The Second Department of Internal Medicine,Sanya Hospital of Traditional Chinese Medicine,SanyaHainan 572000,China)

机构地区：[1]海南省三亚市中医院内二科,海南三亚572000

出　　处：《新疆医科大学学报》2023年第7期914-919,共6页Journal of Xinjiang Medical University

基　　金：海南省卫生健康行业科研项目(21A200364)。

摘　　要：目的探讨心脏运动康复对急性心肌梗死(AMI)患者行经皮冠状动脉介入术(PCI)后心功能和血清载脂蛋白E(apoE)、载脂蛋白B(apoB)水平的影响。方法选取2019年8月-2020年9月三亚市中医院内二科148例成功进行PCI的AMI患者,随机分为对照组与研究组,各74例。对照组采取常规药物治疗与常规护理干预,研究组在此基础上给予心脏运动康复干预。比较两组患者干预前后心功能指标[左室射血分数(LVEF)、左室舒张末期内径(LVEDD)、左室收缩末期内径(LVESD)、左心室收缩末期容积(LVESV)、左心室舒张末期容积(LVEDV)]、血清apoE、apoB水平与6分钟步行试验(6 MWT/m)水平,分析血清apoE、apoB水平及心功能指标的相关性。干预后对患者进行随访比较两组不良事件发生率。结果与干预前比较,对照组与研究组干预后的LVEF、LVEDD、LVESD、LVESV、LVEDV、6 MWT/m等指标均改善,且相对于对照组,研究组各项心功能指标和6 MWT/m改善更明显(P均<0.05)。与干预前比较,对照组与研究组干预后的apoE和apoB水平均降低,且相较于对照组,研究组apoE和apoB水平降低更明显(P均<0.05)。干预前后,两组apoE表达水平与LVEDD、LVESD、LVESV呈正相关,与6MWT/m呈负相关;干预前后两组apoB表达水平与LVESD、LVEDV呈显著正相关(P均<0.05)。干预后,研究组不良事件总发生率(5.41%)显著低于对照组(17.57%)(P<0.05)。结论AMI患者PCI术后给予心脏运动康复干预可显著改善患者心功能与血清apoE、apoB水平。Objective The purpose of this study was to explore the effects of cardiac rehabilitation on cardiac function and serum levels of apolipoprotein E(apoE)and apolipoprotein B(apoB)in patients with acute myocardial infarction(AMI)after percutaneous coronary intervention(PCI).Methods A total of 148 AMI patients who underwent successful PCI in the hospital from August 2019 to September 2020 were randomly divided into a control group and a study group,with 74 cases in each group.The control group received routine drug treatment and nursing intervention,while the study group received cardiac rehabilitation intervention on this basis.The cardiac function parameters[(left ventricular ejection fraction,LVEF),(left ventricular end-diastolic diameter,LVEDD),(left ventricular end-systolic diameter,LVESD),(left ventricular end-systolic volume,LVESV),(left ventricular end-diastolic volume,LVEDV)],serum levels of apoE and apoB,and The 6 min walk test(6 MWT/m)were compared between the two groups before and after the intervention.The correlation between theserum levels of apoE,apoB,6 MWT/mand the cardiac function parameters were analyzed.After the intervention,the patients were followed up,and the incidence of adverse events were recorded in the both groups.Results Compared with before the intervention,the cardiac function parameters including LVEF,LVEDD,LVESD,LVESV,LVEDV and 6 MWT/m in both the control group and the study group were improved after the intervention,and the improvement in the study group was more significant than that in the control group(P<0.05).The serum levels of apoE and apoB in the control group and the study group were decreased after the intervention,and the decreasing in the study group was more significant than that in the control group(P<0.05).Before and after the intervention,the expression levels of apoE and apoB in both groups were positively correlated with LVEDD,LVESD and LVESV,and it negatively correlated with 6 MWT/m.The apoB expression levels and LVESD and LVEDV before and after the intervention(P<

关 键 词：心脏运动康复 急性心肌梗死 经皮冠状动脉介入治疗 载脂蛋白 

分 类 号：R541.4[医药卫生—心血管疾病]