91首治疗糖尿病失眠的中医药处方用药规律分析  

Analysis of 91 Chinese medicine prescriptions for treating diabetic insomnia

作　　者：郑容 王兰 张天朗 刘超男[2] 万晓刚[2] ZHENG Rong;WANG Lan;ZHANG Tianlang;LIU Chaonan;WAN Xiaogang(Guangzhou University of Traditional Chinese Medicine,Guangzhou 510405,China;Department of Endocrinology,the First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine,Guangzhou 510405,China)

机构地区：[1]广州中医药大学,广州510405 [2]广州中医药大学第一附属医院内分泌科,广州510405

出　　处：《新疆医科大学学报》2023年第7期951-956,共6页Journal of Xinjiang Medical University

基　　金：国家自然青年科学基金项目(81803958)。

摘　　要：目的探讨中医药治疗糖尿病失眠患者的组方用药规律。方法检索中国知网(China national knowledge infrastructure,CNKI)建库以来至2022年12月发表的有关中医药治疗糖尿病失眠患者的文献资料,经筛选、提取处方数据并进行规范化处理后使用中医传承计算平台V3.0分析用药规律。结果收集方剂91首,涉及144味中药;其中最常用的中药类别为补虚、清热、安神类;四气特点以寒、平、温性为主;五味以甘、苦、辛味为常用;归经以入肝、心、肺、脾、肾经为主;应用频率较高的药物有生酸枣仁、黄连、首乌藤、生地黄、丹参;常用药物组合有生酸枣仁-丹参、生酸枣仁-首乌藤、丹参-五味子;以熵聚类方式挖掘新方3首。结论中医药治疗糖尿病失眠患者以补虚药为主,佐用安神类药物,结合糖尿病的病机特点可配伍清热类药物。Objective To explore the prescription and medication rules of traditional Chinese medicine in the treatment of diabetic insomnia.Methods Retrieve the literature on the treatment of insomnia patients with diabetes by traditional Chinese medicine published from the establishment of the database of China national knowledge infrastructure(CNKI)until December 2022.After screening,extracting prescription data and carrying out standardized processing,using the traditional Chinese medicine inheritance computing platform V3.0 to analyze the law of drug use.Results A total of 91 prescriptions involving 144 Chinese herbs were collected in the study.The most commonly used Chinese medicinals were tonifying deficiency,clearing heatand tranquilizing.The four qi were characterized by cold,flat and warm.The five flavors including sweet,bitter and pungent were commonly used.Meridian entry was mainly through the liver,heart,lung,spleenand kidney meridians.The drugs with higher application frequency included Semen Ziziphi Spinosae,Rhizoma Coptidis,Caulis Polygoni Multiflori,Radix Rehmanniaeand Radix Salviae Miltiorrhizae.The commonly used herbal combinations were raw Semen Ziziphi Spinosae-Radix Salviae Miltiorrhizae,raw Semen Ziziphi Spinosae-Caulis Polygoni Multiflori,and Radix Salviae Miltiorrhizae-Fructus Schisandrae.This study digged out three new prescriptions.Conclusion The treatment of insomnia patients with diabetes by traditional Chinese medicine is mainly based on tonifying deficiency drugs,supplemented with sedative drugs,and combined with the pathogenesis of diabetes,it can be compatible with antipyretic drugs.

关 键 词：糖尿病 失眠 数据挖掘 用药规律 

分 类 号：R259[医药卫生—中西医结合]