2型糖尿病肺损害容积变化的相关性研究  

Correlation Study on the Changes of Lung Injury Volume in Patients with Type 2 Diabetes Mellitu

作　　者：贺程成 屈兆宇 袁若涵 黄晓旗 李锦红[1] 李延静[1] HE Cheng-cheng;QU Zhao-yu;YUAN Ruo-han;HUANG Xiao-qi;LI Jin-hong;LI Yan-jing(Department of Radiology,Yanan University Affiliated Hospital,Yanan 716000,Shanxi Province,China)

机构地区：[1]延安大学附属医院影像科,陕西延安716000

出　　处：《中国CT和MRI杂志》2023年第7期46-48,共3页Chinese Journal of CT and MRI

基　　金：延安市科技攻关计划项目(2018KS-11);延安市科技惠民计划(2017-HM-07-01)。

摘　　要：目的通过定量CT探讨伴有一氧化碳弥散(DLCO)受损的2型糖尿病患者肺部结构的变化。方法回顾性收集101例伴有DLCO的2型糖尿病患者影像资料后纳入实验组,另73名肺功能无明显异常的2型糖尿病患者纳入对照组,影像资料经“数字肺”处理得出各项CT定量参数,主要包括双肺容积、LAA910%、LAA950%、LAA910、LAA950、及平均密度。通过Mann-Whitney U检验或独立样本t检验对两组肺部定量参数进行差异性分析,采用ROC方法分析T2DM肺部CT定量参数对2型糖尿病弥散功能受损患者的诊断效能。结果实验组肺通气功能参数(FEV1、FEV1%FVC、FVC%)及弥散功能参数(DLCO)相较于对照组显著降低(P<0.05),而肺部CT定量指标全肺容积、LAA 910%、LAA910%、LAA910、LAA950相较于对照组显著降低(P<0.05),平均密度显著增高(P<0.05)。肺通气功能参数(FEV1、FVC、FVC%、DLCO)与全肺容积、LAA910、LAA950、LAA910%、LAA950%呈正相关,与平均密度呈负相关。全肺容积区分T2DM肺弥散功能受损的诊断效能最高,AUC为741。结论通过定量CT可检测T2DM患者存在肺部容积变化,并对T2DM肺弥散功能损害有着良好的诊断效能。Objective Quantitative CT was used to investigate the changes of lung structure in type 2 diabetic patients with carbon monoxide diffusion(DLCO)damage.Methods The imaging data of 101type 2 diabetic patients with DLCO were retrospectively collected and included in the experimental group,and the other 73 type 2 diabetic patients with normal pulmonary function were included in the control group.The quantitative parameters of CT were obtained by"digital lung"processing,including bilateral lung volume,LAA910%,LAA950%,LAA910,LAA950,and average density.The difference of pulmonary quantitative parameters between the two groups was analyzed by Mann-WhitneyU test or independent sample t test,and the diagnostic efficacy of T2DM pulmonary CT quantitative parameters in patients with impaired diffusion function in type 2 diabetes mellitus was analyzed by ROC method.Result Compared with the control group,the pulmonary ventilation function parameters(FEV1,FEV1%FVC,FVC%)and diffusion function parameters(DLCO)in the experimental group were significantly lower than those in the control group,while the whole lung volume,LAA910%,LAA910%,LAA910 and LAA950 were significantly lower and the average density was significantly higher in the experimental group than in the control group.Pulmonary ventilation function parameters(FEV1,FVC,FVC%,DLCO)were positively correlated with whole lung volume,LAA910,LAA950,LAA910%and LAA950%,and negatively correlated with average density.The diagnostic efficacy of whole lung volume in distinguishing the impairment of pulmonary diffusion function in T2DM was the highest,with an AUC of 741.Conclusion Quantitative CT can be used to detect the changes of lung volume in patients with T2DM,and has a good diagnostic efficacy for the impairment of pulmonary diffusion function in T2DM.

关 键 词：糖尿病 肺功能 肺损害 CT 定量分析 

分 类 号：R445.3[医药卫生—影像医学与核医学] R734.2[医药卫生—诊断学]