NAFLD合并CAP患者肝脾CT比值变化及其与冠状动脉粥样斑块性质的统计学关系初步研究  

Preliminary Study on the Change of Liver and Spleen CT Ratio in NAFLD Patients with CAP and Its Statistical Relationship with the Nature of Coronary Atherosclerotic Plaque

作　　者：刘勇 张兴强 Liu Yong;Zhang Xing-qiang(Department of Radiology,Enshi Central Hospital,Enshi 445000,Hubei Province,China)

机构地区：[1]恩施州中心医院放射科,湖北恩施445000

出　　处：《中国CT和MRI杂志》2023年第7期71-73,共3页Chinese Journal of CT and MRI

基　　金：湖北省科技计划项目(2017FFB6412)。

摘　　要：目的采用初步统计学方法探究非酒精性脂肪性肝病(NAFLD)合并冠状动脉硬化斑块(CAP)患者肝脾CT比值变化及其与斑块类型、性质的关系。方法选取我院2018年3月至2020年5月NAFLD合并CAP患者72例作为病例组,另按照2:1原则选取单纯NAFLD患者36例作为对照组。比较两组临床资料、血脂指标[总胆固醇(TC)、甘油三脂(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)]、肝功能指标[谷丙转氨酶(ALT)、天门冬氨酸转氨酶(AST)、尿酸(UA)]水平、肝(L)脾(S)CT比值(L/S比值),评价L/S比值与血脂指标、肝功能指标相关性,分析NAFLD合并CAP的影响因素,比较病例组不同L/S比值患者斑块类型、性质分布情况,分析L/S比值与斑块类型、性质的关系。结果两组BMI、吸烟、合并糖尿病、高血压、血清TC、TG、HDL-C、LDL-C、ALT、AST差异有统计学意义(P<0.05);病例组L/S比值低于对照组,差异有统计学意义(P<0.05);L/S比值与血清TC、TG、LDL-C、ALT、AST呈负相关,与HDL-C呈正相关(P<0.05);BMI、吸烟、合并糖尿病、高血压、UA、L/S比值是NAFLD合并CAP的重要影响因素(P<0.05);不同L/S比值患者斑块类型、性质分布情况对比,差异有统计学意义(P<0.05);L/S比值与斑块稳定性、性质呈负相关(P<0.05)。结论L/S比值、合并糖尿病、合并高血压等多因子与NAFLD合并CAP有关,但L/S比值可为临床评估NAFLD合并CAP风险及斑块特征提供量化参考,对指导早期制定干预策略具有一定价值。Objective To preliminarily explore the change of the ratio of liver and spleen CT in patients with nonalcoholic fatty liver disease(NAFLD)combined with coronary atherosclerotic plaque(CAP)and its statistical relationship with the type and nature of plaque.Methods From March 2018 to May 2020 in our hospital,72 patients with NAFLD and CAP were selected as the case group,and 36 patients with NAFLD were selected as the control group according to the 2:1 principle.The clinical data,blood lipid indexes[total cholesterol(TC),triglycerides(TG),high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C)],liver function indexes[alanine aminotransferase(ALT),aspartate aminotransferase(AST),uric acid(UA)]levels,the CT ratio of liver(L)/spleen(S)(L/S ratio)were compared between the two groups.The correlation between L/S ratio and blood lipid indexes and liver function indexes was evaluated,and the influencing factors of NAFLD complicated with CAP were analyzed.The type and nature of plaque distribution of patients with different L/S ratios in the case group were compared,and the relationship between the L/S ratio and the type and nature of plaques was analyzed.Results The differences in BMI,smoking,diabetes mellitus,hypertension,serum TC,TG,HDL-C,LDL-C,ALT and AST between the two groups were statistically significant(P<0.05).The L/S ratio of the case group was lower than that of the control group,and the difference was statistically significant(P<0.05).The L/S ratio was negatively correlated with serum TC,TG,LDL-C,ALT,AST,and positively correlated with HDL-C(P<0.05).BMI,smoking,diabetes mellitus,hypertension,UA and L/S ratio were important influencing factors for NAFLD complicated with CAP(P<0.05).There was a statistically significant difference in the distribution of plaque types and properties in patients with different L/S ratios(P<0.05).The L/S ratio was negatively correlated with the stability and nature of plaques(P<0.05).Conclusion L/S ratio,diabetes,hypertension and other factors are related

关 键 词：非酒精性脂肪性肝病 冠状动脉硬化斑块 血脂 谷丙转氨酶 甘油三脂 

分 类 号：R543.12[医药卫生—心血管疾病]