机构地区:[1]Center for Advanced Systems Understanding(CASUS),Helmholtz-Zentrum Dresden-Rosendorf(HZDR),G€orlitz,Germany [2]Dept.of Biology,University of Maryland,College Park,MD,USA [3]Dept.of Ecological Modelling,Helmholtz Centre for Environmental Research-UFZ,Leipzig,Germany
出 处:《Infectious Disease Modelling》2023年第2期514-538,共25页传染病建模(英文)
基 金:funded by the Center of Advanced Systems Understanding(CASUS)which is financed by Germany's Federal Ministry of Education and Research(BMBF);by the Saxon Ministry for Science,Culture and Tourism(SMWK)with tax funds on the basis of the budget approved by the Saxon State Parliament.
摘 要:The severe shortfall in testing supplies during the initial COVID-19 outbreak and ensuing struggle to manage the pandemic have affirmed the critical importance of optimal supplyconstrained resource allocation strategies for controlling novel disease epidemics.To address the challenge of constrained resource optimization for managing diseases with complications like pre-and asymptomatic transmission,we develop an integro partial differential equation compartmental disease model which incorporates realistic latent,incubation,and infectious period distributions along with limited testing supplies for identifying and quarantining infected individuals.Our model overcomes the limitations of typical ordinary differential equation compartmental models by decoupling symptom status from model compartments to allow a more realistic representation of symptom onset and presymptomatic transmission.To analyze the influence of these realistic features on disease controllability,we find optimal strategies for reducing total infection sizes that allocate limited testing resources between‘clinical’testing,which targets symptomatic individuals,and‘non-clinical’testing,which targets non-symptomatic individuals.We apply our model not only to the original,delta,and omicron COVID-19 variants,but also to generically parameterized disease systems with varying mismatches between latent and incubation period distributions,which permit varying degrees of presymptomatic transmission or symptom onset before infectiousness.We find that factors that decrease controllability generally call for reduced levels of non-clinical testing in optimal strategies,while the relationship between incubation-latent mismatch,controllability,and optimal strategies is complicated.In particular,though greater degrees of presymptomatic transmission reduce disease controllability,they may increase or decrease the role of nonclinical testing in optimal strategies depending on other disease factors like transmissibility and latent period length.Importantly,our
关 键 词:Testing quarantine control Optimal resource allocation Presymptomatic transmission Latent period Incubation period Age of infection
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