Monkeypox:A comprehensive review of a multifaceted virus  

作　　者：Randa Elsheikh Abdelrahman M.Makram Tamilarasy Vasanthakumaran Shubham Tomar Khizer Shamim Nguyen Dong Tranh Sara S.Elsheikh Nguyen Thanh Van Nguyen Tien Huy 

机构地区：[1]Deanery of Biomedical Sciences at Edinburgh Medical School,University of Edinburgh,Edinburgh EH105HF,United Kingdom [2]Online Research Club(http://www.onlineresearchclub.org),Nagasaki 852-8523,Japan [3]School of Public Health,Imperial College London,London SW72BX,United Kingdom [4]Global Clinical Scholars Research Training,Harvard Medical School,Boston,MA 02115,USA [5]Tata Memorial Hospital,Varanasi 400012,India [6]DataQ Health,Karachi 75100,Pakistan [7]Department of Infection Control,Binh Dinh Provincial General Hospital,Binh Dinh 55000,Vietnam [8]Faculty of Medicine,Zagazig University,Zagazig 44519,Egypt [9]School of Tropical Medicine and Global Health,Nagasaki University,Nagasaki 852-8523,Japan

出　　处：《Infectious Medicine》2023年第2期74-88,共15页感染医学（英文）

摘　　要：In May 2022,the world witnessed the re-emergence of the zoonotic disease monkeypox.While this was not the first epidemic of this disease,what differentiated the outbreak was the rapid global spread and increase of cases,which led the WHO to declare monkeypox a global health emergency.Although the disease spreads mainly through inadequately cooked meat of various rodent species,this virus also shows droplet,respiratory,sexual,and even vertical transmission.Monkeypox further multiplies in lymphoproliferative organs and presents with a classical smallpox-like rash,fever,headache,and muscle aches.Diagnosis is confirmed with a polymerase-chain-reaction test and is managed largely supportively with possible usage of some antivirals and immunoglobulins.Moreover,some pre-exposure and postexposure prophylactic vaccines have been developed.This paper aims to conduct an in-depth review of the historical epidemics,transmission,pathophysiology,clinical presentation,and management of the monkeypox disease.

关 键 词：MONKEYPOX ORTHOPOXVIRUS OUTBREAK SMALLPOX 

分 类 号：R511[医药卫生—内科学]