A new chloro-azaphilone derivative with pro-angiogenesis activity from the hadal trench-derived fungus Chaetomium globosum YP-106  

作　　者：Yaqin FAN Chunjiao JIANG Peihai LI Cong WANG Hao CHEN 

机构地区：[1]MNR Key Laboratory of Marine Eco-Environmental Science and Technology,First Institute of Oceanography,Ministry of Natural Resources,Qingdao 266061,China [2]Shandong Provincial Key Laboratory of Applied Mycology,School of Life Sciences,Qingdao Agricultural University,Qingdao 266109,China [3]Engineering Research Center of Zebrafish Models for Human Diseases and Drug Screening of Shandong Province,Shandong Provincial Engineering Laboratory for Biological Testing Technology,Key Laboratory for Biosensor of Shandong Province,Biology Institute,Qilu University of Technology(Shandong Academy of Sciences),Jinan 250103,China [4]Key Laboratory of Chemistry and Engineering of Forest Producer,State Ethnic Affairs Commission,Guangxi Key Laboratory of Chemistry and Engineering of Forest Products,Guangxi Collaborative Innovation Center for Chemistry and Engineering of Forest Products,School of Chemistry and Chemical Engineering,Guangxi Minzu University,Nanning 53006,China

出　　处：《Journal of Oceanology and Limnology》2023年第3期1145-1151,共7页海洋湖沼学报（英文）

基　　金：Supported by the National Natural Science Foundation of China(No42006096);the Shandong Provincial Natural Science Foundation(No ZR2020QD098);the China Postdoctoral Science Foundation(No2020M682266)。

摘　　要：A new chloro-azaphilone derivative chaetoviridin L(1)along with four known analogues,namely,chaetomugilin A(2),chaetoviridin E(3),chaetomugilin O(4),and chaephilone D(5),is isolated and identified from the culture extract of Chaetomium globosum YP-106,a deep-sea derived fungus obtained from the hadal zone seawater collected in the Yap Trench.Their structures were determined based on detailed interpretation of nuclear magnetic resonance(NMR)spectroscopic,mass spectrometry(MS)data analysis and comparison with the reported literature.The absolute configuration of the new compound was established by quantum chemical calculations of electronic circular dichroism(ECD).All the isolated compounds were evaluated for pro-angiogenesis activity using zebra fish model.Compounds 1,2,and 5significantly promoted the angiogenesis in a dose-dependent manner and thus,these compounds might be used as promising molecules for the treatment of cardiovascular disease.

关 键 词：marine natural products marine-Keyword:marine nabta globosum pro-angjogo nesis activity 

分 类 号：R284[医药卫生—中药学]