转录因子T-bet在慢性阻塞性肺疾病发病中作用的研究进展  

Research progress on the role of transcription factor T-bet in the pathogenesis of chronic obstructive pulmonary disease

作　　者：陈瑜婷 黄玲[2] 夏俊杰[2] 邱宇[2] 弋可 王金诚 CHEN Yuting;HUANG Ling;XIA Junjie;QIU Yu;YI Ke;WANG Jincheng(Department of Respiratory and Critical Care Medicine,Clinical Medical College,Southwest Medical University,Luzhou 646000;Department of Respiratory and Critical Care,the Third People's Hospital of Mianyang(Sichuan Mental Health Center),Mianyang 621054;Department of Respiratory and Critical Care Medicine,Sichuan Science City Hospital,Mianyang 621054;Department of Respiratory and Critical Care Medicine,Zhongjiang County People's Hospital,Deyang 618199,China)

机构地区：[1]西南医科大学临床医学院呼吸与危重症医学科,四川泸州646000 [2]绵阳市第三人民医院(四川省精神卫生中心)呼吸与危重症学科,四川绵阳621054 [3]四川省科学城医院呼吸与危重症医学科,四川绵阳621054 [4]中江县人民医院呼吸与危重症医学科,四川德阳618199

出　　处：《基础医学与临床》2023年第8期1322-1325,共4页Basic and Clinical Medicine

基　　金：四川省卫生健康科研课题基金(19PJ218)。

摘　　要：慢性阻塞性肺疾病(COPD)是一种慢性进行性发展的呼吸系统疾病。转录因子T-bet在抗炎作用、免疫调节等方面参与COPD发病的炎性反应及肺功能改变,有望成为防治COPD发病的新靶点,为COPD的靶向研究提供新思路。Chronic obstructive pulmonary disease(COPD)is a chronic and progressive respiratory disease.Transcription factor T-bet is involved in the inflammatory response and lung function changes of COPD,which is expected to become a new target for the prevention and treatment of COPD.It might provide a new idea for the targeted research of COPD.

关 键 词：T-BET TH1细胞 TH2细胞 TH17细胞 慢性阻塞性肺疾病 

分 类 号：R563[医药卫生—呼吸系统]