核壳结构纳米纤维在口腔组织再生中的应用  

Application of core-shell structured nanofibers in oral tissue regeneration

作　　者：尹彤 杨吉垒 李友瑞 刘卓冉 姜明 Yin Tong;Yang Jilei;Li Yourui;Liu Zhuoran;Jiang Ming(Department of Stomatology,Affiliated Hospital of Binzhou Medical University,Binzhou 256600,Shandong Province,China;Department of Stomatology,Dezhou Hospital of Traditional Chinese Medicine,Dezhou 253000,Shandong Province,China;First Department of Dental and Pulp Diseases,Jinan Stomatological Hospital,Jinan 250000,Shandong Province,China)

机构地区：[1]滨州医学院附属医院口腔修复科,山东省滨州市256600 [2]德州市中医院口腔科,山东省德州市253000 [3]济南市口腔医院牙体牙髓病1科,山东省济南市250000

出　　处：《中国组织工程研究》2024年第5期766-770,共5页Chinese Journal of Tissue Engineering Research

基　　金：山东省医药卫生科技发展项目(2017WS753),项目负责人:李友瑞;滨州医学院科技计划项目(2016KJ06),项目负责人:李友瑞。

摘　　要：背景:核壳结构纳米纤维因具有良好的生物力学性能、可控的药物释放及多功能性相结合受到越来越多的关注,也使其在口腔组织再生领域有着广泛的应用前景。目的:针对核壳结构纳米纤维的制备、载药类型及释放原理以及在口腔组织再生修复中的应用研究作一综述。方法:应用计算机检索中国知网、PubMed数据库2000年1月至2022年11月收录的文献,中英文检索词分别为“静电纺丝、核壳结构、药物传递系统、颌骨再生、软骨再生、牙周组织再生”和“electrospinning、core-shell structures、drug delivery systems、jaw bone regeneration、cartilage regeneration、periodontal tissue regeneration”。结果与结论:①核壳结构纳米纤维的制备方法多样,其中同轴法和乳液法静电纺丝具有操作简单、材料选择多样性和生物相容性良好等独特优势;②核壳结构纳米纤维可作为抑菌剂、不同类型药物载体及细胞黏附的支架,为口腔组织再生提供了新的治疗方案;③核壳结构纳米纤维可控的降解及药物释放速率可以更好地适应口腔组织缺损修复愈合过程,实现组织理想再生。BACKGROUND:The combination of good biomechanical properties,controlled drug release and multi-functionality of core-shell structured nanofibers is receiving more and more attention,which also makes them promising for a wide range of applications in the field of oral tissue regeneration.OBJECTIVE:To summarize the preparation,drug loading and release mechanisms of core-shell structured nanofibers and their application in the regenerative repair of oral tissues.METHODS:A computer search of the literature collected in CNKI and PubMed from January 2000 to November 2022 was applied,and the search terms in English and Chinese were“electrospinning,core-shell structures,drug delivery systems,jaw bone regeneration,cartilage regeneration,periodontal tissue regeneration”.RESULTS AND CONCLUSION:(1)There are various methods for the preparation of core-shell structured nanofibers,but the coaxial and emulsion methods of electrostatic spinning have unique advantages such as simple operation,diverse material selection and good biocompatibility.(2)Core-shell structured nanofibers can be used as bacteriostatic agents,carriers of different types of drugs,and scaffolds for cell adhesion,providing new therapeutic options for oral tissue regeneration.(3)Controlled degradation and drug release rate of core-shell structured nanofibers can better adapt to the healing process of oral tissue defect repair and achieve ideal tissue regeneration.

关 键 词：静电纺丝 核壳结构 纳米纤维 药物传递系统 骨再生 软骨再生 牙周组织再生 

分 类 号：R459.9[医药卫生—治疗学] R318.08[医药卫生—临床医学] R-1