微弧氧化处理对医用金属生物活性的影响  

Effect of micro-arc oxidation treatment on biological activity of medical metals

作　　者：王业元 杜易朗 于德浩 宁凤婷 白冰[2] Wang Yeyuan;Du Yilang;Yu Dehao;Ning Fengting;Bai Bing(School of Stomatology,China Medical University,Shenyang 110001,Liaoning Province,China;Second Department of Prosthodontics,Hospital of Stomatology,China Medical University,Liaoning Institute of Stomatology,Shenyang 110001,Liaoning Province,China)

机构地区：[1]中国医科大学口腔医学院,辽宁省沈阳市110001 [2]中国医科大学附属口腔医院修复二科,辽宁省口腔医学研究所,辽宁省沈阳市110001

出　　处：《中国组织工程研究》2024年第5期771-776,共6页Chinese Journal of Tissue Engineering Research

基　　金：东北大学-中国医科大学国家级大学大学生创新项目(220268),项目参与者:白冰。

摘　　要：背景:在众多金属植入物表面改性技术中,微弧氧化技术因操作方便、成本低且能有效调整表面涂层的微观结构和元素而得到广泛关注。目的:总结微弧氧化技术在不同材料表面制备氧化涂层的理化性能及生物活性的研究进展。方法:应用计算机检索PubMed和Web of Science数据库中有关于微弧氧化技术对医用金属生物活性影响的文献,英文检索词为“MAO、micro-arc oxidation、osseointegration、mechanical property、biological activity、angiogenesis、fibrogenesis”,检索时间范围是2016年1月至2022年12月。根据纳入与排除标准,最终纳入82篇文献进行综述。结果与结论:微弧氧化技术是一种极具潜力的表面改性技术,可以极大提高种植体植入的成功率,也可以广泛应用于其他领域,具体原因如下:①微弧氧化技术在材料表面形成特殊多孔形貌,可以优化其耐磨性、耐腐蚀性等机械性能,降低镁合金的降解速率;②微弧氧化技术可以通过在材料多孔形貌中掺入锶、羟基磷灰石和其他金属或非金属物质,辅助提高其成骨分化、血管生成、纤维生成等生物活性,改善钛和钛合金生物惰性的缺点。BACKGROUND:Among the surface modification technologies of metal implants,micro-arc oxidation has been widely concerned for its convenience,low cost and ability to effectively adjust the microstructure and elements of surface coatings.OBJECTIVE:To summarize research advances in physical and chemical properties and biological activities of oxidation coatings prepared by micro-arc oxidation on different materials.METHODS:The articles about the effects of micro-arc oxidation on the biological activity of medical metals were searched in PubMed and Web of Science based on the English search terms“MAO,micro-arc oxidation,osseointegration,mechanical property,biological activity,angiogenesis,fibrogenesis”.The search time was from January 2016 to December 2022.According to the inclusion and exclusion criteria,82 articles were finally retained for review.RESULTS AND CONCLUSION:Micro-arc oxidation is a potential surface modification technology,which can greatly improve the success rate of implantation,and can be widely used in other fields.The specific reasons are as follows:(1)Micro-arc oxidation technology forms special porous morphology on the surface of materials,which can optimize the mechanical properties such as wear resistance and corrosion resistance,contributing to the reduction of the degradation rate of magnesium alloys.(2)Micro-arc oxidation technology can significantly enhance the bioactivity and improve the bioinertness of titanium and titanium alloys through the addition of strontium,hydroxyapatite and other metallic or nonmetallic substances to its porous morphology for helping elevate its osteogenic differentiation,angiogenesis,fibrogenesis and other biological activities.

关 键 词：微弧氧化 医用金属 表面形貌 弹性模量 耐腐蚀性 生物活性 成骨性能 血管生成 

分 类 号：R459.9[医药卫生—治疗学] R318.08[医药卫生—临床医学] R-1