金属有机框架与种植体表面改性及其应用  

Application of metal-organic frameworks in implant surface modification

作　　者：尹楷文 李运峰[1] Yin Kaiwen;Li Yunfeng(Hospital of Stomatology,Sichuan University&State Key Laboratory of Oral Diseases&National Clinical Research Center for Oral Diseases,Chengdu 610041,Sichuan Province,China)

机构地区：[1]四川大学华西口腔医院正颌及关节外科,口腔疾病研究国家重点实验室,国家口腔疾病临床医学研究中心,四川省成都市610041

出　　处：《中国组织工程研究》2024年第5期783-788,共6页Chinese Journal of Tissue Engineering Research

基　　金：国家重点研发计划项目(2022YFB3804500),项目参与人:李运峰;四川省自然科学基金面上项目(2023NSFSC0570),项目负责人:李运峰。

摘　　要：背景:近年来,金属有机框架由于其特有性质在生物医学领域应用广泛,可以将金属有机框架应用于种植体表面改性,以改善其生物学性能,提高手术成功率。目的:介绍种植体表面改性领域常用的金属有机框架以及种植体表面金属有机框架改性的制备和作用机制。方法:采用计算机检索中国知网、PubMed和Web of Science数据库中有关金属有机框架应用于种植体表面改性的研究资料,选取发表于2010-2023年的相关文献,最终纳入64篇文献进行综述分析。结果与结论:①金属有机框架具有孔隙率高、比表面积大及空间结构多样等性质,作为一种生物活性材料,金属有机框架在组织工程和再生医学中逐渐引起重视。②种植体改性领域常用的金属有机框架类型主要有3种:类沸石骨架材料最常作为载体应用,负载各种药物和生物分子,MIL系列材料适用于药物载体和纳米酶,Bio-金属有机框架因结构多样而应用广泛,突出特点是优异的生物安全性。③金属有机框架改性的种植体材料制备方法大致分为两类,第一类是将已合成的金属有机框架结合到预处理植入材料上,第二类是在预处理的材料表面原位合成金属有机框架。④种植体表面的金属有机框架通过降解释放自身组分、负载药物、催化活性反应及与其他材料联合等多种机制,赋予种植体抗菌抗炎促进骨整合的特性,但金属有机框架涂层制备方法还需要进一步完善,同时应深入探究材料后续代谢和分布问题,积极推动其在临床上的应用。BACKGROUND:In recent years,metal-organic frameworks have been widely used in the biomedical field because of their unique properties,and metal-organic frameworks can be applied to implant surface modification for improving their biological properties and the surgery’s success rate.OBJECTIVE:To introduce metal-organic frameworks commonly used in implant surface modification and the preparation and action mechanism of surgical implants modified by metal-organic frameworks.METHODS:The articles concerning metal-organic frameworks used in implant surface modification published from 2010 to 2023 were searched on PubMed,Web of Science and CNKI.Finally,64 articles were included for review.RESULTS AND CONCLUSION:(1)Metal-organic frameworks have the properties of high porosity,large specific surface area,and diverse spatial structure.As bioactive material,metal-organic frameworks have attracted much attention in tissue engineering and regenerative medicine.(2)The metal-organic frameworks commonly used in the field of implant surface modification include three types.Zeolitic imidazolate frameworks are commonly used as carriers,carrying various drugs and biomolecules.The MIL series are suitable for drug carriers and nanoenzymes.Bio-metal-organic frameworks have many applications because of their diverse structure and are characterized by excellent biosafety.(3)The preparation of implant materials modified by metal-organic frameworks can be mainly divided into two types:one is to incorporate metal-organic frameworks into pretreated implants;the other is to synthesize metal-organic frameworks in situ on pretreated implants.(4)Metal-organic frameworks on the implant surface could release their components,load drugs,catalyze active reactions,or combine with other materials,giving implants antibacterial and anti-inflammatory characteristics and promoting osseointegration.The preparation method of metal-organic framework coatings needs further improvement,and the metabolism and distribution of metal-organic framework coatings sh

关 键 词：金属有机框架 生物医学应用 种植体 表面改性 骨整合 涂层 生物安全性 预处理 

分 类 号：R459.9[医药卫生—治疗学] R318[医药卫生—临床医学] R363