联合磷酸肌酸钠和曲美他嗪对酒精性心肌病大鼠的超声心动图及心脏血清学相关指标的影响  

Effects of combined creatine phosphate sodium and trimetazidine on echocardiography and cardiac serology-related indexes in rats with alcoholic cardiomyopathy

作　　者：李晓栋 李金国[1] 游素君 LI Xiaodong;LI Jinguo;YOU Sujun(Cardiac Ultrasound Room,Union Hospital Affiliated to Fujian Medical University,Fuzhou 350001,China)

机构地区：[1]福建医科大学附属协和医院心脏彩超室,福州350001

出　　处：《中国实验动物学报》2023年第5期635-642,共8页Acta Laboratorium Animalis Scientia Sinica

基　　金：福建省财政专项经费资助(2016B042)。

摘　　要：目的探讨联合磷酸肌酸钠和曲美他嗪对酒精性心肌病大鼠的超声心动图及心脏血清学相关指标的影响。方法通过慢性酒精灌胃法建立酒精性心肌病大鼠模型,将成功建模后的大鼠随机分为:磷酸肌酸钠组(CPS组)、曲美他嗪组(TMZ组)、磷酸肌酸钠+曲美他嗪组(CPS+TMZ组)、生理盐水组(NS组)、酒精组(AL组),实验共为期8周。运用超声心动图测量大鼠左室舒张末期内径(LVEDd)、室间隔舒张末期厚度(IVSDd)、左室后壁舒张末期厚度(LVPWDd)、左心室射血分数(EF),并检测血清肌酸激酶同工酶(CK-MB)、高敏肌钙蛋白I(Hs-TnI)、乳酸脱氢酶(LDH)以及氨基末端脑钠尿肽(Nt-proBNP)。结果(1)较AL组及NS组,CPS组与TMZ组的LVEDd降低,EF升高,CK-MB、Hs-TnI及LDH均降低;(2)较CPS组与TMZ组,CPS+TMZ组的LVEDd降低,EF升高,CK-MB、Hs-TnI、LDH及Nt-proBNP均降低;(3)CPS组与TMZ组间的各指标均无统计学差异。结论磷酸肌酸钠与曲美他嗪均对酒精性心肌病具有一定的治疗效果,且二者联合应用的效果优于二者单用。Objective To investigate the effect of combined sodium creatine phosphate and trimetazidine on echocardiography and cardiac serology in rats with alcoholic cardiomyopathy.Methods A rat model of alcoholic cardiomyopathy was established by chronic alcohol gavage.After successful modeling,rats were randomly divided into creatine phosphate(CPS),trimetazidine(TMZ),creatine phosphate+trimetazidine(CPS+TMZ)group,normal saline group(NS),and alcohol(AL)groups.The study was conducted for 8 weeks.Echocardiography was used to measure left ventricular end-diastolic diameter(LVEDd),ventricular septal end-diastolic thickness(IVSDd),left ventricular posterior wall end-diastolic thickness(LVPWDd),and left ventricular ejection fraction(EF).Serum creatine kinase CK-MB,high-sensitivity troponin I(Hs-TnI),lactate dehydrogenase(LDH),and amino-terminal brain natriuretic peptide(Nt-proBNP)were also measured.Results (1)Compared with AL and NS groups,LVEDd was decreased,EF was increased,and CK-MB,Hs-TnI,and LDH were decreased in CPS and TMZ groups.(2)Compared with CPS and TMZ groups,LVEDd was decreased,EF was increased,and CK-MB,Hs-TnI,LDH,and Nt-proBNP were decreased in the CPS+TMZ group.(3)There was no statistical difference in each index between CPS and TMZ groups.Conclusions Both creatine phosphate and trimetazidine have a therapeutic effect on alcoholic cardiomyopathy,and their combined effect is better than that of either alone.

关 键 词：酒精性心肌病 磷酸肌酸钠 曲美他嗪 超声心动图 血清学指标 

分 类 号：Q95-33[生物学—动物学]