HIV动物模型在毒品滥用研究中的应用  

Application of a HIV animal model in drug abuse research

作　　者：王婵 杨根梦 刘柳 王浩伟 苗霖 李怡 李娟 曾晓锋 WANG Chan;YANG Genmeng;LIU Liu;WANG Haowei;MIAO Lin;LI Yi;LI Juan;ZENG Xiaofeng(Department of Forensic Medicine,School of Forensic Medicine,Kunming Medical University,Kunming 650500,China;Department of Pathogen Biology and Immunology,Faculty of BasicMedical Science,Kunming Medical University,Kunming 650500;NHC Key Laboratory ofDrug Addiction Medicine,Kunming 650500)

机构地区：[1]昆明医科大学法医学院法医学系,昆明650500 [2]昆明医科大学基础医学院病原生物学与免疫学系,昆明650500 [3]国家卫健委毒品依赖和戒治重点实验室,昆明650500

出　　处：《中国实验动物学报》2023年第5期653-659,共7页Acta Laboratorium Animalis Scientia Sinica

基　　金：国家自然科学基金(82160325,82060382,82202081);云南省科技厅-昆明医科大学应用基础研究联合专项(重点项目)(202201AY070001-020)。

摘　　要：目前,毒品滥用及人类免疫缺陷病毒(human immunodeficiency virus,HIV)感染的共病问题备受关注。毒品滥用是HIV传播的促发因素之一,其同样可加重HIV感染者中枢神经系统的病毒载量水平和加速HIV相关神经认知障碍(HIV-associated neurocognitive disorders,HAND)的疾病进展速度。本文着重介绍了目前常用的HIV感染相关动物模型,如非人灵长类动物、啮齿类动物及猫科动物,分析了其局限性和优势性,并对HIV感染相关动物模型在毒品滥用研究中的应用进行了综述。The comorbidity of drug abuse and human immunodeficiency virus(HIV)infection has attracted much attention.Drug abuse is a promoter of HIV transmission.It also aggravates the viral load in the central nervous system and accelerates the progression of HIV-associated neurocognitive disorders.This article focuses on the commonly used animal models related to HIV infection,such as non-human primates,rodents,and felines,analyzes their limitations and advantages,and summarizes the latest research progress of animal models related to HIV infection in drug abuse.

关 键 词：人类免疫缺陷病毒 毒品滥用 非人灵长类动物模型 HIV感染相关啮齿类动物模型 FIV/家猫动物模型 

分 类 号：Q95-33[生物学—动物学]