Trilayered Fibrous Dressing with Wettability Gradient for Spontaneous and Directional Transport of Massive Exudate and Wound Healing Promotion  

作　　者：Lei Liu Hengqiu Sun Jiaming Zhang Bingjie Xu Yujie Gao Dongming Qi Zhengwei Mao Jindan Wu 

机构地区：[1]MOE Key Laboratory of Advanced Textile Materials&Manufacturing Technology,Zhejiang Sci-Tech University,Hangzhou 310018,China [2]Department of Pediatric Surgery,Taizhou Women and Children’s Hospital of Wenzhou Medical University,Taizhou 318000,China [3]MOE Key Laboratory of Macromolecular Synthesis and Functionalization,Department of Polymer Science and Engineering,Zhejiang University,Hangzhou 310027,China

出　　处：《Advanced Fiber Materials》2023年第2期574-587,共14页先进纤维材料（英文）

基　　金：supported by a grant from the National Natural Science Foundation of China(51973195);Zhejiang Provincial Key Research and Development Program(2020C03042);“Ten Thousand Plan”-Zhejiang Provincial High Level Talents Special Support Plan(2020R52023).

摘　　要：Excessive exudate at wound sites increases treatment difficulty and severely decelerates the healing process.In wound exu-date management,dressings with unidirectional liquid transport capability have exhibited enormous potential.However,it remains challenging to improve the one-way liquid transport efficiency.Herein,a trilayered fibrous dressing is constructed by sequentially electrospinning polyurethane(PU)and polyvinylidene fluoride(PVDF)onto cotton fabric.Through hot pressing,a stable wettability gradient is formed across the PVDF/PU/cotton dressing due to the melting and bridging of PU nanofib-ers.The trilayered dressing exhibited rapid unidirectional transport with water penetrating from the hydrophobic side to the hydrophilic side in 6 s.The hydrostatic pressure from the hydrophilic side to the hydrophobic side is 569%higher than that from the hydrophobic side to the hydrophilic side,indicating that the dressing has a profound unidirectional conductivity.In vivo experiments demonstrates that the trilayered dressing can accelerate the wound healing process,especially in the early stages of wound occurrence,by quickly draining the excessive exudate.This study provides a new method to construct wound dressings with wettability gradients,which are advantageous for efficient exudate removal.

关 键 词：Trilayered fibrous dressing Exudate pumping PU nanofibers Wettability gradient Wound healing 

分 类 号：R318[医药卫生—生物医学工程]