Control of Surface Wrinkles on Shape Memory PLA/PPDO Micro‑nanofibers and Their Applications in Drug Release and Anti‑scarring  

作　　者：Lu Wang Jingyi Ma Tao Guo Fenghua Zhang Aimeng Dong Shiqi Zhang Yanju Liu Huiping Yuan Jinsong Leng 

机构地区：[1]Centre for Composite Materials and Structures,Harbin Institute of Technology(HIT),No.2 Yikuang Street,Harbin 150080,People’s Republic of China [2]The Department of Ophthalmology,The Future Medicine Laboratory,The Second Affiliated Hospital of Harbin Medical University,No.246 Xuefu Street,Harbin 150086,People’s Republic of China [3]Department of Astronautic Science and Mechanics,Harbin Institute of Technology(HIT),No.92 West Dazhi Street,Harbin 150001,People’s Republic of China

出　　处：《Advanced Fiber Materials》2023年第2期632-649,共18页先进纤维材料（英文）

基　　金：supported by the National Natural Science Foundation of China(Grant No.11802075,12072094,81870654,and 82070956);the Fundamental Research Funds for the Central Universities(No.IR2021106 and IR2021232);Applied Technology Research and Development Program of Heilongjiang Provincial Science and Technology Department(GA20C008).

摘　　要：Micro-and nano-fibers of shape memory polymers(SMP)offer multiple advantages like high specific surface area,poros-ity,and intelligence,and are suitable for biomedical applications.In this study,biodegradable poly(p-dioxanone)(PPDO)materials were incorporated to improve the brittleness of shape memory polylactic acid(PLA),and plasticizers were used to reduce the transition temperature of SMP composites such that their transitions could be induced close to body temperature.Furthermore,an electrostatic spinning technology was applied to prepare SMP fibers with wrinkled structures and regulate their microstructures and morphologies such that the intelligent transition of wrinkled and smooth morphologies can be achieved on the fiber surface.The application of this controllable-morphology fiber membrane in intelligent controlled drug release and scar inhibition after Ahmed Glaucoma Valve(AGV)implantation was also studied.The drug release from the stretched and deformed drug-loaded fiber membranes was faster than those from membranes with the original shape.This membrane with micro-and nano-fibers had good anti-scarring effects that improved after drug loading.The achievement of intelligent controlled drug release and the evident anti-scarring effects of the membrane broaden the application of SMP fibers in the biomedical field.

关 键 词：Shape memory polymers Micro-nano fibers Wrinkled structure Smart controlled release of drugs Anti-scarring 

分 类 号：R318[医药卫生—生物医学工程]