Temperature‑Gated Light‑Guiding Hydrogel Fiber for Thermoregulation During Optogenetic Neuromodulation  

作　　者：Guoyin Chen Siming Xu Qiangqiang Zhou Yuejiao Zhang Yuhan Song Jing Mi Yuehua Liu Kai Hou Jie Pan 

机构地区：[1]Department of Orthodontics,Shanghai Stomatological Hospital and School of Stomatology,Fudan University,Shanghai 200001,China [2]State Key Laboratory for Modification of Chemical Fibers and Polymer Materials,College of Materials Science and Engineering,Donghua University,2999 North Renmin Road,Shanghai 201620,China

出　　处：《Advanced Fiber Materials》2023年第3期968-978,共11页先进纤维材料（英文）

基　　金：supported by the Shanghai Stomatological Hospital Science and Technology Talents Project(SSH-2022-KJCX-B01);National Key Research and Development Program of China(2021YFA1201302/2021YFA1201300);the National Natural Science Foundation of China(NO.52173029;NO.51733002;NO.51803022);Guoyin Chen thanks for the support from the fellowship of China National Postdoctoral Program for Innovative Talents under Grant BX20220063,and Graduate Student Innovation Fund of Donghua University(CUSF-DH-D-2020038).

摘　　要：With the rise of optogenetic manipulation of neurons,the effects of optogenetic heating on temperature-sensitive physi-ological processes,and the damage to surrounding tissues have been neglected.This manuscript reports the fabrication of a highly temperature-sensitive semi-interpenetrating optical hydrogel fiber(TSOHF)using the integrated dynamic wet-spinning technique.TSOHF exhibits a structural tunable diameter,clear core/sheath structure,tunable temperature-sensitivity,excellent light propagation property(0.35 dB cm^(-1),650 nm laser light),and good biocompatibility(including tissue-like Young’s modulus,stable dimensional stability,and low cytotoxicity).Based on these properties,a potential application of optogenetic regulation of neural tissue(hypoglossal nerve),with controllable temperature using TSOHF was designed and performed.Further,this work provides new insight into molecular design and a practical approach to continually manufacture a temperature-sensitive hydrogel optical fiber for applications in intelligent photomedicine.

关 键 词：TEMPERATURE-SENSITIVE Light-guiding Fiber THERMOREGULATION Optogenetic 

分 类 号：TQ427.26[化学工程]