基于LIS数据库使用Hoffman法和Bhattacharya法建立长春地区老年人群微量元素的参考区间  

Establishment of Trace Elements Reference Intervals for Elderly in Changchun by Hoffman and Bhattacharya Method Based on LIS Database

作　　者：柴佳彤 孙泽宇 许建成[1] Chai Jiatong;Sun Zeyu;Xu Jiancheng(Department of Laboratory Medicine,The First Hospital of Jilin University,Changchun 130021)

机构地区：[1]吉林大学白求恩第一医院检验科,长春130021

出　　处：《国际老年医学杂志》2023年第4期412-418,共7页International Journal of Geriatrics

基　　金：吉林省科技发展计划基金项目(20190304110YY)。

摘　　要：目的使用Hoffman法和Bhattacharya法建立长春地区≥60岁老年人群的微量元素参考区间。方法选取2020年7月~2020年12月吉林大学白求恩第一医院体检中心≥60岁的健康体检者2304例,其中男1078例,女1226例,以5岁为1个年龄组分成60~64岁(1025例)、65~69岁(701例)、70~74岁(296例)、75~79岁(175例)、≥80岁(107例)五组。采用HarrisandBoyd′s检验法、单因素方差分析等统计学方法分析不同性别、不同年龄组间差异,分别采用Hoffman法和Bhattacharya法建立参考区间。结果①男性和女性组间的血清钙、镁、锌差异无统计学意义(Z<Z^(*)),男性和女性的血清铜和血清铁差异有统计学意义(Z>Z^(*))。LMS图显示血清钙水平在80岁后呈上升趋势;血清镁水平呈下降趋势;血清锌在70~80岁之间下降,随后上升;男性血清铁随年龄增长明显下降,女性血清铁水平随年龄增长轻微增高;血清铜水平总体呈上升趋势。②使用Hoffman法和Bhattacharya法建立的参考区间均通过验证。Hoffman法得到的参考区间为:血清钙2.11~2.43mmol/L(≥60岁);血清镁0.80~1.08mmol/L(≥60岁);血清锌8.82~16.36μmol/L、8.16~15.82μmol/L(60~74岁、≥75岁);男性血清铁11.54~30.78μmol/L(60~79岁)、7.94~28.12μmol/L(≥80岁);女性血清铁10.71~26.33μmol/L(≥60岁);男性血清铜11.89~19.38μmol/L(≥60岁);女性血清铜13.38~21.84μmol/L(≥60岁)。Bhattacharya法得到的参考区间为:血清钙2.14~2.46mmol/L(≥60岁);血清镁0.84~1.10mmol/L(≥60岁);血清锌8.86~17.05μmol/L、8.15~16.44μmol/L(60~74岁、≥75岁);男性血清铁12.67~32.95μmol/L、7.62~30.42μmol/L(60~79岁、≥80岁);女性血清铁10.92~28.17μmol/L(≥60岁);男性血清铜12.06~20.10μmol/L(≥60岁);女性血清铜13.43~23.42μmol/L(≥60岁)。结论基于LIS中数据使用Hoffman法和Bhattacharya法建立适用于老年人群的微量元素参考区间,可为后续研究提供方法学参考。长春地区血清铁、血清锌和血清铜显示出了性�Objective This study aimed to determine reference intervals(RIs)for trace elements in the elderly population(≥60 years old)residing in Changchun city,utilizing both the Hoffman and Bhattacharya methods.Methods The sample population consisted of 2304 participants(1078 males and 1226 females)selected from the physical examination center between July 2020 and December 2020.Participants were stratified into five groups based on five-year age intervals:60-64 years old(1,025 cases),65-69 years old(701 cases),70-74 years old(296 cases),75-79 years old(175 cases),and 80 years old and above(107 cases).Statistical analyses,including Harris and Boyd's test and one-way ANOVA,were employed to assess group differences.RIs were established using both the Hoffman and Bhattacharya methods.Results There was no statistically significant difference in serum calcium(Ca),magnesium(Mg),and zinc(Zn)levels between males and females(Z<Z^(*)),however,a significant difference was observed in serum copper(Cu)and iron(Fe)levels(Z>Z^(*)).Analysis using the LMS chart revealed an upward trend in serum Ca levels among individuals aged 80 years and above,while serum Mg levels exhibited a decreasing trend.Serum Zn levels decreased between the ages of 70 and 80,followed by an increasing trend in the group aged 80 years and above.In males,serum Fe levels significantly decreased with age,while females showed a slight increase.Serum Cu levels exhibited an upward trend across all five age groups.The established RIs using both the Hoffman and Bhattacharya methods were validated.The RIs obtained using the Hoffman method were as follows:for individuals aged 60 years and above,the RI for serum Ca levels was 2.11-2.43 mmol/L,and for serum Mg levels,it was 0.80-1.08 mmol/L.The RI for serum Zn levels varied between 8.82-16.36μmol/L for those aged 60-74 years and 8.16-15.82μmol/L for individuals aged 75 years and above.In males,the RI for serum Fe levels ranged from 11.54-30.78μmol/L for those aged 60-79 years and 7.94-28.12μmol/L for those aged 80 years

关 键 词：微量元素 参考区间 Hoffman法 Bhattacharya法 LIS数据库 

分 类 号：R592[医药卫生—老年医学]