热应激影响奶牛胚胎发育作用机制的研究进展  

Research Progress on the Mechanism of Heat Stress Affecting the Development of Dairy Cow Embryos

作　　者：张航 杨柏高 徐茜 冯肖艺 杜卫华[1] 郝海生[1] 朱化彬[1] 张培培 赵学明[1] ZHANG Hang;YANG Baigao;XU Xi;FENG Xiaoyi;DU Weihua;HAO Haisheng;ZHU Huabin;ZHANG Peipei;ZHAO Xueming(Institute of Animal Science,Chinese Academy of Agricultural Sciences,Beijing 100193,China)

机构地区：[1]中国农业科学院北京畜牧兽医研究所,北京100193

出　　处：《畜牧兽医学报》2023年第7期2692-2700,共9页ACTA VETERINARIA ET ZOOTECHNICA SINICA

基　　金：国家重点研发计划政府间重点专项(2022YFE0100200);国家自然科学基金国际合作项目(32161143032);农业农村部和财政部资助:现代农业产业技术体系资助(CARS-36);国家家养动物种质资源库;中国农业科学院科技创新工程(ASTIP-IAS06)。

摘　　要：奶牛热应激是高温环境引起的奶牛生理上的非特异性反应,会严重影响奶牛自身生理状态,损害胚胎发育,进而造成巨大经济损失。因此,如何提高热应激条件下奶牛胚胎发育能力,对于促进奶牛养殖业健康发展意义重大。本文就热应激对奶牛内分泌、卵母细胞及胚胎的负面影响,以及物理降温、激素治疗、添加IGF1、基因编辑技术修饰HSPA1L和PRLR基因等解决措施进行综述,为促进热应激奶牛胚胎发育提供一定参考。Heat stress of dairy cows is a non-specific physiological reaction caused by high tempera-ture environment,which can seriously affect the physiological state and embryonic development of dairy cows,and then cause huge economic losses.Therefore,how to improve the development ability of dairy cow embryos under heat stress is of great significance to promote the healthy development of dairy cattle breeding industry.In this paper,the negative effects of heat stress on endocrine,oocytes and embryos of dairy cows,as well as the solution measures such as physical cooling,hormone therapy,addition of IGF1,modification of HSPA 1L and PRLR genes by gene editing technology were reviewed,so as to provide some reference for improving the develop-ment ability of dairy cow embryos under heat stress.

关 键 词：奶牛 热应激 卵母细胞 胚胎 

分 类 号：S823.91[农业科学—畜牧学]