An anti-aging skin strategy:promoting repair and regeneration in UV-induced photoaging micro-environment using growth factors-rich platelet lysates composite Self-protection Collagen Hydrogel  

作　　者：Jian-Peng Zhang Zi-Duo Huang Bing-Qing Wang Yi-Xin Chen Qing-Qing Zhou Hui-Qin Li Xin-Sheng Peng Yan-Fang Zhou 

机构地区：[1]Department of Pathophysiology,Guangdong Medical University,Dongguan 523808,China [2]Department of Pharmacy,Guangdong Medical University,Dongguan 523808,China

出　　处：《Biomedical Engineering Communications》2023年第2期7-17,共11页生物医学工程通讯

基　　金：funding from the Discipline construction project of Guangdong Medical University(4SG21277P,2021ZDZX2039,2DK21003,4SG23060G);Our work described in the present manuscript was also supported by research grants from Guangdong Provincial Natural Science Foundation(2021A1515012437,2021KTSCX040),Guangdong,China。

摘　　要：Skin photoaging is induced and sustained by UV-induced oxidative damage,and stimulating regeneration of the UV-induced aging has remained a great challenge due to high-level oxidative stress factor(ROS)-induced chronic oxidative damage and inactivation of bio-macromolecule-based regeneration in oxidative photoaging micro-environment.In this study,we designed a“seed and soil”strategy to pursue a safer and more efficient way to prevent and treat photoaging by simultaneously changing UV-induced ROS-rich micro-environment into a proregenerative one(the“soil”)and providing growth factor-rich platelet lysates(PL,the“seed”)using PL-impregnated,collagen-reinforce hydrogel(PL/Col).SD rats were used to establish photoaging model by 8 weeks of UV irradiation.The effectiveness of different treatments was evaluated by making pathological sections and detecting photoaging-related indicators.Rats treated with PL/Col demonstrated a significant acceleration in skin healing and enhancement in the quality of trauma repairing.After treated with PL/Col,the rats showed smooth yellowish appearance,integral structure of skin collagen fiber and epidermis,a decrease in inflammation and a reshaped active micro-environment with reduced levels of SOD enzyme activity,GSH enzyme activity and MDA toxic products.Treatment of PL/Col in skin photoaging has shown potential anti-oxidation and anti-aging effects and is worthy of further study in related field.

关 键 词：PHOTOAGING platelet derivatives oxidative stress growth factors collagen trauma repair 

分 类 号：R28[医药卫生—中药学]