中药黄蜀葵花治疗糖尿病肾病研究进展  

Research Progress of Treating Diabetic Kidney Disease with Abelmoschus Manihot

作　　者：钱琦 周悦欣 安晓飞[1] QIAN Qi;ZHOU Yuexin;AN Xiaofei(Affiliated Hospital of Nanjing University of Chinese Medicine,Jiangsu Provincial Hospital of Traditional Chinese Medicine,Nanjing,Jiangsu,China,210029)

机构地区：[1]南京中医药大学附属医院,江苏南京210029

出　　处：《河南中医》2023年第8期1257-1264,共8页Henan Traditional Chinese Medicine

基　　金：国家自然科学基金项目(82074359);全国西学中骨干人才培训项目(2019-44)。

摘　　要：糖尿病肾脏病(diabetic kidney disease,DKD)是指由糖尿病(diabetes mellitus,DM)引起的慢性代谢性肾脏病,包括肾脏结构和功能的异常,主要表现为持续性蛋白尿和进行性肾功能减退,是导致终末期肾病(end-stage renal disease,ESRD)的首要原因,严重影响DM患者生活质量和预期寿命。近年来大量研究表明,中药黄蜀葵花(abelmoschus manihot,AM)在降低DKD蛋白尿和改善肾脏损伤方面疗效显著。AM具有较好的肾脏保护作用并可改善DKD患者的临床症状。AM治疗DKD的药理机制主要包括减轻炎症反应、抗氧化应激、减轻肾小球高滤过状态和硬化、减轻肾小管损伤和肾间质纤维化、减少足细胞凋亡、改善胰岛素抵抗和调节脂质代谢等。本文就AM治疗DKD蛋白尿和肾脏损伤的临床疗效和细胞分子机制的进展进行阐述,有助于其广泛应用于未来的临床实践。Diabetes kidney disease(DKD)is a chronic metabolic kidney disease caused by diabetes mellitus(DM),including abnor⁃malities of renal structure and function,mainly manifested as persistent proteinuria and progressive renal dysfunction,which is the pri⁃mary cause of end⁃stage renal disease(ESRD)and seriously affects the quality of life and life expectancy of DM patients.In recent years,a large number of research has shown that the abelmoschus manihot(AM)has significant therapeutic effects in reducing DKD proteinuria and improving kidney damage.AM has good renal protective effects and can improve the clinical symptoms of DKD patients.The pharmacological mechanisms of AM in treating DKD mainly include reducing inflammatory response,antioxidant stress,alleviating glomerular hyperfiltration and sclerosis,alleviating renal tubular injury and interstitial fibrosis,reducing foot cell apoptosis,improving in⁃sulin resistance,and regulating lipid metabolism,This article elaborates on the clinical efficacy and cellular and molecular mechanisms of AM in the treatment of DKD proteinuria and kidney injury,which will contribute to its widespread application in future clinical prac⁃tice.

关 键 词：黄蜀葵花 糖尿病肾病 蛋白尿 

分 类 号：R244.9[医药卫生—针灸推拿学]