Swarming Responsive Photonic Nanorobots for Motile-Targeting Microenvironmental Mapping and Mapping-Guided Photothermal Treatment  

作　　者：Luolin Li Zheng Yu Jianfeng Liu Manyi Yang Gongpu Shi Ziqi Feng Wei Luo Huiru Ma Jianguo Guan Fangzhi Mou 

机构地区：[1]State Key Laboratory of Advanced Technology for Materials Synthesis and Processing,Wuhan University of Technology,Wuhan 430070,People’s Republic of China [2]School of Materials and Microelectronics,Wuhan University of Technology,Wuhan 430070,People’s Republic of China [3]School of Materials Science and Engineering,Wuhan University of Technology,Wuhan 430070,People’s Republic of China [4]School of Chemistry,Chemical Engineering and Life Science,Wuhan University of Technology,Wuhan 430070,People’s Republic of China

出　　处：《Nano-Micro Letters》2023年第9期205-223,共19页纳微快报（英文版）

基　　金：supported by the National Key Research and Development Project(No.2021YFA1201400);National Natural Science Foundation of China(Nos.52073222,51573144 and 21474078);the Fundamental Research Funds for the Central Universities(WUT:2021IVA118 and 2022IVA201).

摘　　要：Micro/nanorobots can propel and navigate in many hard-to-reach biological environments,and thus may bring revolutionary changes to biomedical research and applications.However,current MNRs lack the capability to collectively perceive and report physicochemical changes in unknown microenvironments.Here we propose to develop swarming responsive photonic nanorobots that can map local physicochemical conditions on the fly and further guide localized photothermal treatment.The RPNRs consist of a photonic nanochain of periodically-assembled magnetic Fe_(3)O_(4)nanoparticles encapsulated in a responsive hydrogel shell,and show multiple integrated functions,including energetic magnetically-driven swarming motions,bright stimuli-responsive structural colors,and photothermal conversion.Thus,they can actively navigate in complex environments utilizing their controllable swarming motions,then visualize unknown targets(e.g.,tumor lesion)by collectively mapping out local abnormal physicochemical conditions(e.g.,pH,temperature,or glucose concentra-tion)via their responsive structural colors,and further guide external light irradiation to initiate localized photothermal treatment.This work facilitates the development of intelligent motile nanosensors and versatile multifunctional nanotheranostics for cancer and inflam-matory diseases.

关 键 词：Micro/nanorobots Collective behaviors Responsive photonic crystals On-the-fly sensing Photothermal therapy 

分 类 号：TB383.1[一般工业技术—材料科学与工程] R318[医药卫生—生物医学工程]