上行网状激活系统与睡眠-觉醒和全身麻醉的研究进展  

Research progress of ascending reticular activating system on sleep-wake and general anesthesia

作　　者：廖蹇豪 袁杰 秦榜勇 LIAO Jianhao;YUAN Jie;QIN Bangyong(Department of Anesthesiology,Affiliated Hospital of Zunyi Medical University,Guizhou Key Laboratory of Anesthesia and Organ Protection,Zunyi 563000,China)

机构地区：[1]遵义医科大学附属医院麻醉科、贵州省麻醉与器官保护基础研究重点实验室,563000

出　　处：《临床麻醉学杂志》2023年第6期654-658,共5页Journal of Clinical Anesthesiology

基　　金：国家自然科学基金地区基金项目(82160683,81960660);贵州省科技厅基础研究计划(202042940112211125);贵州省教育厅青年科技人才成长项目(黔教合KY字〔2018〕240号);遵义医科大学附属医院博士启动基金(院字〔2018〕12号)。

摘　　要：全身麻醉如何导致意识的可逆性消失是探究全身麻醉机制的核心内容。近年来,经过脂质学说、蛋白学说和离子通道学说三个阶段后,全身麻醉与神经通路之间的联系已成为研究热点。目前的研究表明,全身麻醉状态与生理性睡眠存在一定相似之处。上行网状激活系统包含多种神经元及核团,通过投射及释放相关神经递质,促进并维持生物的觉醒,而全身麻醉药也共享了其中的某些通路及递质。本文通过综述近年上行网状激活系统中关键核团在睡眠-觉醒过程中作用机制的研究进展,探讨网状激活系统与睡眠-觉醒、全身麻醉的关系,为阐明全身麻醉的药物作用机制、探寻临床治疗睡眠障碍新方法提供参考。How general anesthetics induce reversible unconsciousness remains unknown.Recently,after three stages of lipid theory,protein theory and ion channel theory,the relationship between general anesthesia and sleep-arousal pathways has become a research hotspot.Current research shows that general anesthesia and natural sleep share the common feature of reversible unconsciousness.The ascending reticular activating system contains a variety of neuronal nuclei,which promote and maintain the awakening state of organisms by projecting and releasing related neurotransmitters.The purpose of this review is to explore the relationship among ascending reticular activating system,sleep-arousal and general anesthesia,so as to provide reference for clarifying the mechanism of general anesthetics and developing new methods for clinical treatment of sleep disorders.

关 键 词：上行网状激活系统 觉醒 全身麻醉 基底前脑 结节乳头核 腹侧被盖区 

分 类 号：R614.2[医药卫生—麻醉学]