肺泡气一氧化氮联合呼出气一氧化氮对支气管哮喘的诊断价值  

Value of Alveolar Nitric Oxide and Fractional Exhaled Nitric Oxide in The Diagnosis of Bronchial Asthma

作　　者：柴静 CHAI Jing(Respiratory and Digestive Medicine Department of The People's Hospital of Jizhou District,Tianjin 301900,China)

机构地区：[1]天津市蓟州区人民医院呼吸消化科,天津蓟州301900

出　　处：《罕少疾病杂志》2023年第7期35-36,共2页Journal of Rare and Uncommon Diseases

摘　　要：目的评价肺泡气一氧化氮(alveolar nitric oxide,CaNO)检测联合呼出气一氧化氮(fractional exhaled nitric oxide,FeNO)对哮喘的诊断价值。方法收集天津市蓟州区人民医院呼吸科2021年3~11月份就诊的有反复发作性喘息、胸闷、咳嗽等症状的可疑支气管哮喘患者共74例,所有患者均行肺功能检查及CaNO、FeNO检测,并以2016年中国支气管哮喘防治指南[1]作为金标准,评价CaNO联合FeNO对支气管哮喘的诊断价值。结果确诊支气管哮喘患者41例,其余33例为非哮喘患者。以CaNO值7.56ppb为阈值,诊断支气管哮喘的敏感度为75.6%,特异度为72.7%,以FeNO值32.5ppb为阈值,敏感度为78%,特异度为75.8%。两者联合检测时,敏感度为80.5%,特异度为81.8%,相比单独检测差异显著,有统计学意义(P<0.05)。结论CaNO和FeNO联合检测对诊断支气管哮喘具有更高的敏感性和特异性,可作为辅助诊断依据。Objective To explore the diagnostic of CaNO combined with FeNO in bronchial asthma.Methods A total of 74 patients with unknown-cause respiratory symptoms including gasping,dyspnea and cough were enrolled from July to December in 2021.FeNO,CaNO and lung function tests were performed,and positive dilation test was used as the gold standard for the diagnosis of asthma.The Chinese guidelines for bronchial asthma of 2016 was defined as golden standard for asthma diagnosis.All patients were tested for CaNO,FeNO and pulmonary function;the sensitivity and specificity were determined by the means of the receiver operating characteristic(ROC)curves.Results 41 cases of asthma and 33 cases of nonasthma were diagnosed by pulmonary function examination.The optimal CaNO cutoff point was 7.56ppb which was capable of differentiating asthma and non-asthma with sensitivity of 75.6%,specificity of 72.7%.The optimal FeNO cutoff value for asthma diagnosis was 32.5ppb,with the sensitivity of 78%,specificity of 75.8%.The sensitivity of the combined test were80.5%and the specificity was 81.8%.Between single test and the combined test exist significant differences,P<0.05.Conclusion CaNO and FeNO combined detection may be more helpful in the diagnosis of asthma with high sensitivity and specificity.

关 键 词：肺泡气一氧化氮 呼出气一氧化氮 支气管哮喘 诊断 

分 类 号：R562[医药卫生—呼吸系统]