DC-CIK细胞生物疗法结合同步放化疗在中晚期肺小细胞癌中的临床应用  

Clinical Application of DC-CIK cell Biological Therapy Combined with Concurrent Chemoradiotherapy in Advanced Lung Small Cell Carcinoma

作　　者：钟新云 龙瀛 Zhong Xin-yun;Long Ying(Internal three departments of Wanzai County People's Hospital,Yichun 336100,China)

机构地区：[1]万载县人民医院内三科,江西宜春336100

出　　处：《罕少疾病杂志》2023年第7期57-58,共2页Journal of Rare and Uncommon Diseases

摘　　要：目的探讨DC-CIK细胞生物疗法结合同步放化疗在中晚期非小细胞癌(NSCLC)中的临床应用效果。方法选取我院2020年1月至2022年6月期间收治且被病理诊断为NSCLC患者80例,按随机数字表法分为两组,即40例患者为对照组,采用同步放化疗;另40例患者为观察组,在对照组的基础上采用DC-CIK细胞生物疗法;对比两组近期效果、免疫水平等。结果观察组近期控制率82.50%高于对照组的57.50%(P<0.05)。观察组治疗后CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)、NK细胞水平高于对照组,CD8^(+)细胞低于对照组,恶心呕吐、肝肾功能损伤、放射性肺炎、血小板减少发生率低于对照组(P<0.05)。结论DC-CIK细胞生物疗法结合同步放化疗治疗中晚期非小细胞癌,近期效果好,免疫水平明显提高。Objective To investigate the clinical application effect of DC-CIK cell biological therapy combined with concurrent chemoradiotherapy in advanced non-small cell carcinoma(NSCLC).Methods A total of 80 patients admitted to our hospital from January 2020 to June 2022 who were pathologically diagnosed with NSCLC were selected and divided into two groups according to the random number table method,that is,40 patients were used as the control group,and concurrent chemoradiotherapy was used.The other 40 patients were in the observation group,and DC-CIK cell biological therapy was used on the basis of the control group.The short-term effects and immunity levels of the two groups were compared.Results The short-term control rate in the observation group was 82.50%higher than that in the control group(P<0.05).The levels of CD3^(+),CD4^(+),CD4^(+)/CD8^(+)and NK cells in the observation group were higher than those in the control group,and the CD8^(+)cells were lower than those in the control group,and the incidence of nausea and vomiting,liver and kidney function damage,radiation pneumonitis and thrombocytopenia was lower than that in the control group(P<0.05).Conclusion DC-CIK cell biological therapy combined with concurrent chemoradiotherapy in the treatment of advanced non-small cell carcinoma has good short-term effect and significantly improved immunity.

关 键 词：DC-CIK细胞生物疗法 放化疗 中晚期 非小细胞癌 

分 类 号：R322.35[医药卫生—人体解剖和组织胚胎学]