老年类风湿性关节炎患者外周循环中Th17/Treg免疫失衡与疾病活动的相关性  

Correlation between Th17/Treg Immune Imbalance in Peripheral Circulation and Disease Activity in Elderly Patients with Rheumatoid Arthritis

作　　者：赵双 Zhao Shuang(Department of Clinical Laboratory,Yellow River Sanmenxia Hospital,Sanmenxia 472100,Henan Province,China)

机构地区：[1]黄河三门峡医院检验科,河南三门峡472100

出　　处：《罕少疾病杂志》2023年第7期82-84,共3页Journal of Rare and Uncommon Diseases

摘　　要：目的探究老年类风湿性关节炎(elderly onset rheumatoid arthritis,EORA)患者外周循环中Th17/Treg与疾病活动的相关性。方法回顾性分析2019年5月至2022年5月我院风湿免疫科收治的70例EORA患者的临床资料,另选取同期于我院接受体检且身体健康者40例纳入健康对照组。采用流式细胞术检测并计算所有研究对象外周循环中的Th17、Treg占比和Th17/Treg,分析三者与EORA疾病活动评分之间的关系。结果各组间的血清Th17占比、Treg占比和Th17/Treg相比,差异均有统计学意义(P<0.05);与健康对照组相比,EORA各组血清Th17占比、Th17/Treg均更高,血清Treg占比更低,差异有统计学意义(P<0.05);在RA患者中随着疾病活动评分升高,血清Th17占比、Th17/Treg均升高,血清Treg占比则降低,且组间两两比较的差异均有统计学意义(P<0.05)。相关性分析结果显示,血清Th17占比和血清Th17/Treg与疾病活动评分成正相关(r=0.731、0.853,P<0.05),血清Treg占比则与疾病活动评分成负相关(r=-0.484,P<0.05)。结论EORA患者外周循环中Th17占比迅速升高,Treg占比明显降低,过高的Th17/Treg与更严重的疾病活动评分密切相关。Objective To investigate the relationship between Th17/Treg in peripheral circulation and disease activity in Elderly patients with rheumatoid arthritis(EORA).Methods The clinical data of 70 patients with EORA admitted to the Rheumatology and Immunology Department of our hospital from May 2019 to May 2022 were retrospectively analyzed.Another 40 healthy people who underwent physical examination in our hospital during the same period were selected as healthy control group.Flow cytometry was used to detect and calculate the proportion of Th17,Treg and Th17/Treg in peripheral circulation of all subjects,and the relationship between the three and EORA disease activity score was analyzed.Results There were significant differences in serum Th17 ratio,Treg ratio and Th17/Treg ratio among groups(P<0.05).Compared with the healthy control group,the proportion of serum Th17 and Th17/Treg in EORA groups were higher,and the proportion of serum Treg was lower,and the differences were statistically significant(P<0.05).In RA patients,with the increase of disease activity score,the proportion of serum Th17 and Th17/Treg increased,while the proportion of serum Treg decreased,and the differences between the two groups were statistically significant(P<0.05).The results of correlation analysis showed that the proportion of serum Th17 and serum Th17/Treg were positively correlated with disease activity score(r=0.731,0.853,P<0.05),while the proportion of serum Treg was negatively correlated with disease activity score(r=-0.484,P<0.05).Conclusion The proportion of Th17 in peripheral circulation of patients with EORA increases rapidly,while the proportion of Treg decreases significantly.High Th17/Treg ratio is closely related to more severe disease activity score.

关 键 词：类风湿性关节炎 Th17 TREG 疾病活动评分 

分 类 号：R593.22[医药卫生—内科学]