Spatially asymmetric cascade nanocatalysts for enhanced chemodynamic therapy  

作　　者：Minchao Liu Hongyue Yu Liang Chen Tiancong Zhao Meng Fang Mengli Liu Qiaoyu Zhou Fatemah Farraj AlHarbi Ahmed Mohamed El-Toni Fan Zhang Dongyuan Zhao Xiaomin Li 

机构地区：[1]Department of Chemistry,State Key Laboratory of Molecular Engineering of Polymers,iChem,Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials,Fudan University,Shanghai 200433,China [2]Department of Musculoskeletal Cancer Surgery,Fudan University Shanghai Cancer Center,Shanghai 200032,China [3]Department of Physics,College of Science,Princess Nourah bint Abdulrahman University,P.O.Box 84428,Riyadh 11671,Saudi Arabia [4]King Abdullah Institute for Nanotechnology,King Saud University,Riyadh 11451,Saudi Arabia

出　　处：《Nano Research》2023年第7期9642-9650,共9页纳米研究（英文版）

基　　金：This work is supported by the National Natural Science Foundation of China(Nos.22075049,21875043,22088101,21701027,21733003,21905052,and 51961145403);the National Key R&D Program of China(Nos.2018YFA0209401 and 2018YFE0201701);Key Basic Research Program of Science and Technology Commission of Shanghai Municipality(No.17JC1400100);Natural Science Foundation of Shanghai(Nos.22ZR1478900,18ZR1404600,and 20490710600);Fundamental Research Funds for the Central Universities(20720220010);Shanghai Rising-Star Program(No.20QA1401200);The authors express their gratitude to Princess Nourah bint Abdulrahman University Researchers Supporting Project number(PNURSP2023R55);Princess Nourah bint Abdulrahman University,Riyadh,Saudi Arabia.The statements made herein are solely the responsibility of the authors。

摘　　要：Chemodynamic therapy(CDT)based on cascade catalytic nanomedicine has emerged as a promising cancer treatment strategy.However,most of the reported cascade catalytic systems are designed based on symmetric-or co-assembly of multiple catalytic active sites,in which their functions are difficult to perform independently and may interfere with each other.Especially in cascade catalytic system that involves fragile natural-enzymes,the strong oxidation of free-radicals toward natural-enzymes should be carefully considered,and the spatial distribution of the multiple catalytic active sites should be carefully organized to avoid the degradation of the enzyme catalytic activity.Herein,a spatially-asymmetric cascade nanocatalyst is developed for enhanced CDT,which is composed by a Fe_(3)O_(4)head and a closely connected mesoporous silica nanorod immobilized with glucose oxidase(mSiO_(2)-GOx).The mSiO_(2)-GOx subunit could effectively deplete glucose in tumor cells,and meanwhile produce a considerable amount of H_(2)O_(2)for subsequent Fenton reaction under the catalysis of Fe_(3)O_(4)subunit in the tumor microenvironment.Taking the advantage of the spatial isolation of mSiO_(2)-GOx and Fe_(3)O_(4)subunits,the catalysis of GOx and freeradicals generation occur at different domains of the asymmetric nanocomposite,minimizing the strong oxidation of free-radicals toward the activity of GOx at the other side.In addition,direct exposure of Fe_(3)O_(4)subunit without any shelter could further enhance the strong oxidation of free-radicals toward objectives.So,compared with traditional core@shell structure,the long-term stability and efficiency of the asymmetric cascade catalytic for CDT is greatly increased by 138%,thus realizing improved cancer cell killing and tumor restrain efficiency.

关 键 词：MESOPOROUS nanocatalytic medicine chemodynamic therapy asymmetric nanostructure core@shell 

分 类 号：O64[理学—物理化学]