Pillar[6]arene-based supramolecular self-assemblies for twopronged GSH-consumption-augmented chemo/photothermal therapy  

作　　者：Yang Bai Xihua Li Sijie Song Jing Yang Xia Liu Zhaowei Chen 

机构地区：[1]Shaanxi Key Laboratory of Chemical Additives for Industry,College of Chemistry and Chemical Engineering,Shaanxi University of Science and Technology,Xi’an 710021,China [2]Institute of Food Safety and Environment Monitoring,College of Chemistry,Fuzhou University,Fuzhou 350108,China

出　　处：《Nano Research》2023年第7期9921-9929,共9页纳米研究（英文版）

基　　金：This work was supported by the National Natural Science Foundation of China(Nos.21801162,22277011,and 22107019);National Key Research&Development Program of China(No.2020YFA0210800);National Science Basic Research Plan in Shaanxi Province of China(No.2023-JC-QN-0150);the Major Project of Science and Technology of Fujian Province(No.2020HZ06006).

摘　　要：The abundant intracellular glutathione(GSH)in cancer cells severely undermines the therapeutic efficacy of different treatments due to their role in protecting cancer cells from the associated oxidative stress.Developing a highly integrated system to consume GSH would help to improve the therapeutic outcomes.In this study,supramolecular prodrug self-assemblies(SPSAs)with IR825 loaded inside were developed to consume GSH via two-pronged pathways while augmenting the therapeutic potency of chemo/photothermal treatment.SPSAs were prepared using water-soluble pillar[6]arene(WP[6])as host units and H_(2)O_(2)-responsive nitrogen mustard prodrug,chlorambucil-(phenylboronic acid pinacol ester)conjugates(Cb-BE),as the guests.When SPSAs were internalized by cancer cells,the generation of quinone methide(QM)from Cb-BE and singlet oxygen(^(1)O_(2))from irradiation-activated IR825 could consume GSH in a concerted way.As such,the therapeutic efficacies of the released chlorambucil and the accompanied hyperthermia were augmented toward synergistically inhibiting tumor growth.

关 键 词：supramolecular self-assemblies arene glutathione consumption chemo/photothermal therapy 

分 类 号：O62[理学—有机化学]